毒理性
◉ 母乳喂养期间使用总结：本记录中的信息是指将碘化钠 I 131 作为诊断和治疗剂的使用。在哺乳期间使用 I 131 是禁忌的。在给哺乳母亲服用0.01 MBq（0.004 mCi）或更大剂量的碘化钠 I 131 后，应永久停止对这个孩子进行母乳喂养。为了减少对乳房的辐射剂量和乳汁泄漏的风险，建议在接收碘化钠 I 131 治疗剂量前4到6周停止母乳喂养。美国甲状腺协会建议使用 I 123 或 Tc99m 钚酸扫描来诊断哺乳期母亲的甲亢。
在接受治疗性碘131给药后，父母应避免与婴儿密切接触。确切的时间取决于给药剂量、治疗条件和建议来源。推荐的时间范围从甲亢治疗后的15到27天，甲状腺癌消融后的16到24天，以及甲状腺消融治疗后续治疗后的4到5天。
哺乳期母亲不应在工作场所处理含有 I 131 的物质。
◉ 对哺乳婴儿的影响：截至修订日期，未找到相关已发布信息。
◉ 对泌乳和母乳的影响：截至修订日期，未找到相关已发布信息。
◉ Summary of Use during Lactation:Information in this record refers to the use of sodium iodide I 131 as a diagnostic and therapeutic agent. The use of I 131 is contraindicated during lactation. Breastfeeding should be discontinued permanently for this child after administration of sodium iodide I 131 in a dose of 0.01 MBq (0.004 mCi) or greater to a nursing mother. Ceasing breastfeeding 4 to 6 weeks before receiving a therapeutic dose of sodium iodide I 131 is recommended to reduce the radiation dose to the breasts and the risk of milk leakage that can contaminate clothing with radioactive iodine. The American Thyroid Association recommends using I 123 or Tc99m pertechnetate scans for diagnosis of hyperthyroidism in nursing mothers.
Parents should refrain from close contact with their infants after therapeutic iodine 131 administration. The exact duration depends on the dose administered, condition being treated, and source of the recommendation. Recommended times range from 15 to 27 days after hyperthyroidism treatment, 16 to 24 days after ablation of thyroid cancer, and 4 to 5 days after follow-up therapy of thyroid ablation therapy.
Nursing mothers should not work with substances containing I 131 in their workplace.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
