氟锆酸钾

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属盐
• 中文名称: 氟锆酸钾
• 中文别名: 锆氟酸钾；(OC-6-11)-六氟合锆酸(2-)钾；六氟锆(IV)酸钾；氟化锆钾；六氟锆酸钾
• 英文名称: dipotassium;zirconium(4+);hexafluoride
• 化学式: F6K2Zr
• 分子量: 283.41
• InChiKey: BJZIJOLEWHWTJO-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  -23.97
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

毒理性

• 致癌性证据

A4；不能分类为人类致癌物。/氟化物，以F表示/

A4; Not classifiable as a human carcinogen. /Fluorides, as F/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性总结

识别和使用：锆酸钾以白色晶体和无色单斜晶体的形式存在。它用于制造金属锆；作为镁和铝的晶粒细化剂；焊接助熔剂；催化剂；光学玻璃。人类暴露和毒性：目前还没有已知的锆酸钾人类暴露研究。动物研究：锆酸钾在小鼠体内的口服LD50为98毫克/千克。在口服给药的最大耐受剂量250毫克锆酸钾/千克体重下进行测试时，在大鼠骨髓微核研究中，在24小时和48小时两个测试采样时间点均未表现出致突变性。当锆酸钾放入兔子的结膜囊中时，它对眼睛造成了严重损害。

IDENTIFICATION AND USE: Zirconium potassium fluoride is found in the form of white crystals and colorless monoclinic crystals. It is used for the manufacture of metallic zirconium; as a grain refiner in magnesium and aluminum; welding fluxes; catalyst; optical glass. HUMAN EXPOSURE AND TOXICITY: At this time there are no known human exposure studies for zirconium potassium fluoride. ANIMAL STUDIES: The oral LD50 in mice for zirconium potassium fluoride is 98 mg/kg. When it was tested up to the maximum tolerated dose of 250 mg zirconium potassium fluoride/kg bw by oral administration, it showed no mutagenic properties in a rat bone marrow micronucleus study at the two tested sampling times of 24 hours and 48 hours. Zirconium potassium fluoride caused serious damage to the eyes of rabbits when it was placed into the conjunctival sac.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、气囊面罩装置或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或将其置于左侧（如果可能，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于失去意识、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注5%葡萄糖溶液（D5W），保持通道开放，最低流量/ SRP: "保持开放"，最低流量。如果出现低血容量的迹象，使用0.9%生理盐水（NS）或乳酸钠林格氏液（LR）。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。用地西泮（安定）或劳拉西泮（阿提凡）治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。/毒物A和B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  氟锆酸钾 、 氨 生成 氢氧化锆
  参考文献：
  名称：

  NIECKO, JERZY, J. SERB. CHEM. SOC., 53,(1988) N, C. 521-529

  摘要：

  DOI：

文献信息

• NIECKO, JERZY, J. SERB. CHEM. SOC., 53,(1988) N, C. 521-529
  作者：NIECKO, JERZY

  DOI：——

  日期：——