(E)-3-(8-(hydroxyamino)-2-((naphthalen-1-yloxy)methyl)-8-oxo-2-octeneamido)pyrrolidin-1-carboxylic acid t-butylester | 936221-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-3-(8-(hydroxyamino)-2-((naphthalen-1-yloxy)methyl)-8-oxo-2-octeneamido)pyrrolidin-1-carboxylic acid t-butylester
• 英文别名: t-butyl (E)-3-(8-(hydroxyamino)-2-((naphthalen-1-yloxy)methyl)-8-oxo-2-octeneamido)pyrrolidine-1-carboxylate；tert-butyl 3-[[(E)-8-(hydroxyamino)-2-(naphthalen-1-yloxymethyl)-8-oxooct-2-enoyl]amino]pyrrolidine-1-carboxylate
• CAS: 936221-62-4
• 化学式: C₂₈H₃₇N₃O₆
• 分子量: 511.618
• InChiKey: DESQBBSIDDYJNZ-SRZZPIQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• PHARMACEUTICALLY ACCEPTABLE SALT OF ALKYLCARBAMOYL NAPHTHALENYLOXY OCTENOYLHYDROXYAMIDE OR OF DERIVATIVE THEREOF AND METHOD FOR PREPARING SAME
  申请人：CRYSTALGENOMICS, INC.

  公开号：US20200283371A1

  公开（公告）日：2020-09-10

  The present invention relates to a pharmaceutically acceptable salt of alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide or of a derivative thereof and a method for preparing same, and can improve moisture stability while maintaining the characteristics, such as the efficacy and effective dose, of a pharmaceutically acceptable salt of alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide or of a derivative thereof. In addition, the present invention can simplify the production and manufacturing process of a formulation by improving hygroscopicity.

  本发明涉及一种药学上可接受的烷基氨基甲酰基萘氧基辛烯酰羟胺盐或其衍生物的制备方法，能够在保持药学上可接受的烷基氨基甲酰基萘氧基辛烯酰羟胺盐或其衍生物的功效和有效剂量等特性的同时，提高其湿度稳定性。此外，本发明还可以通过提高其吸湿性来简化配方的生产和制造过程。
• [EN] PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF FIBROSIS<br/>[FR] COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE LA FIBROSE<br/>[KO] 섬유화증 예방 또는 치료용 약학 조성물
  申请人：CRYSTALGENOMICS INC

  公开号：WO2019190214A1

  公开（公告）日：2019-10-03

  본 발명은 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드, 이의 유도체, 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 섬유화증의 예방 또는 치료용 약학 조성물에 관한 것으로, 섬유성 조직의 증식을 효과적으로 억제하여 섬유화증을 예방 및/또는 치료하는데 사용될 수 있다.