(S)-(+)-3-methylpiperidine mandelate salt | 77550-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (S)-(+)-3-methylpiperidine mandelate salt
• 英文别名: (3s)-3-Methylpiperidine mandelate；2-hydroxy-2-phenylacetic acid;(3S)-3-methylpiperidine
• CAS: 77550-83-5
• 化学式: C₆H₁₃N*C₈H₈O₃
• 分子量: 251.326
• InChiKey: URNSREQLJROASC-ZCMDIHMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-(+)-3-methylpiperidine mandelate salt 、 苯甲酰氯 以94%的产率得到
  参考文献：
  名称：

  THURKAUF, ANDREW;HILLERY, PAUL;JACOBSON, ARTHUR E.;RICE, KENNER C., J. ORG. CHEM., 52,(1987) N 24, 5466-5467

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-(+)-扁桃酸 、 3-甲基哌啶 以64%的产率得到
  参考文献：
  名称：

  THURKAUF, ANDREW;HILLERY, PAUL;JACOBSON, ARTHUR E.;RICE, KENNER C., J. ORG. CHEM., 52,(1987) N 24, 5466-5467

  摘要：

  DOI：

文献信息

• Phencyclidine derivatives, preparation method and pharmaceutical compositions containing same
  申请人：Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)

  公开号：US06342511B1

  公开（公告）日：2002-01-29

  The invention concerns novel phenylcyclidine derivatives with selective affinity for low affinity receptors, methods for preparing them, pharmaceutical compositions containing them and their use as protective agents for central or peripheral nervous system cells against acute or chronic degeneration, or as an anticonvulsant.

  本发明涉及新型苯环二氮平衍生物，具有选择性亲和力，适用于低亲和力受体，制备方法，包含它们的制药组合物以及它们作为中枢或周围神经系统细胞的保护剂，用于急性或慢性退化，或作为抗癫痫药物的用途。
• NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Bertrand Isabelle

  公开号：US20090111808A1

  公开（公告）日：2009-04-30

  The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

  本专利申请涉及式(I)的化合物，其中R1和R2与它们所连接的氮原子结合形成单环或双环饱和含氮环; 它们的制备及其用作H3受体配体，用于治疗例如阿尔茨海默病等中枢神经系统疾病。
• Histamine H3-receptor ligands and their therapeutic applications
  申请人：Bioprojet

  公开号：US08076329B2

  公开（公告）日：2011-12-13

  The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

  本专利申请涉及公式（I）化合物，其中R1和R2与它们附着的氮原子一起形成单环或双环饱和含氮环；它们的制备以及它们作为H3受体配体用于治疗例如阿尔茨海默病等中枢神经系统疾病。
• Novel Piperidine Derivative
  申请人：Ishikawa Shiho

  公开号：US20090137576A1

  公开（公告）日：2009-05-28

  Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein R1 represents a phenyl group which may be substituted or the like and R2 represents a cyano group which may be substituted or the like, or R1 and R2 together form an aliphatic heterocylic ring which may be substituted; R3 represents a group represented by the formula (II-1) below; and all of X1 to X4 represent a carbon atom or the like: (II-1) where R4 and R5 represent a lower alkyl group or the like; and m1 represents an integer of 2 to 4.

  本发明涉及一种物质，其对组胺与组胺H3受体的结合具有拮抗作用，或对组胺H3受体不断表现的活性具有抑制作用。化合物由式(I)或其药学上可接受的盐表示；(I)其中R1代表可能被取代或类似的苯基团，R2代表可能被取代或类似的氰基团，或R1和R2一起形成可能被取代的脂肪族杂环环；R3代表由下式(II-1)表示的基团；X1到X4都表示碳原子或类似物：(II-1)其中R4和R5代表较低的烷基团或类似物；m1表示2到4的整数。
• Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
  申请人：BIOPROJET

  公开号：EP1717235A2

  公开（公告）日：2006-11-02

  The present patent application concerns new compounds of formula (I), their process of preparation and their therapeutic use.

  本专利申请涉及新的式 (I) 化合物、其制备工艺及其治疗用途。