(μ-4-chloro-2,6-bis[bis(2-methoxyethyl)aminomethyl]phenoxo)-bis(μ-acetato)dizinc(II) tetraphenylborate | 637350-93-7

• 英文名称: (μ-4-chloro-2,6-bis[bis(2-methoxyethyl)aminomethyl]phenoxo)-bis(μ-acetato)dizinc(II) tetraphenylborate
• CAS: 637350-93-7
• 化学式: C₂₄H₂₀B*C₂₄H₄₀ClN₂O₉Zn₂
• 分子量: 986.056
• InChiKey: MDQNXAMEQQPYIZ-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  sodium 4-chloro-2,6-bis[bis(2-methoxyethyl)aminomethyl]phenolate 、 四苯硼钠 、 zinc(II) acetate dihydrate 以 甲醇 为溶剂， 以35%的产率得到(μ-4-chloro-2,6-bis[bis(2-methoxyethyl)aminomethyl]phenoxo)-bis(μ-acetato)dizinc(II) tetraphenylborate
  参考文献：
  名称：

  Aminopeptidase function of dinuclear zinc(II) complexes of phenol-based dinucleating ligands: effect of p-substituents

  摘要：

  The aminopeptidase functions of newly obtained dinuclear zinc(II) complexes [Zn,(bonp)(MeCO2)(2)]BPh4 (1) and [Zn-2(bocp)(Me-CO2)(2)]BPh4 (2) were estimated using (L)-leucine-p-nitroanilide as a substrate [H(bonp): 2,6-bis[bis(2-methoxyethyl)aminomethyl]-4-nitrophenol; H(bocp): 4-chloro-2,6-bis[bis(2-methoxyethyl)aminomethyl]phenol]. Both complexes showed aminopeptidase activities, and a second-order rate equation was obtained as v = k [complex] [substrate]. The second-order rate constants k were 5.9(5) x 10(-1) for complex 1, and 2.7(1) x 10(-2) dm(3) mol(-1) s(-1) for complex 2. Compared to the previously reported complex, [Zn-2(bomp)(MeCO2)(2)]BPh4 (3) [H(bomp): 2,6-bis[bis(2-methoxyethyl)aminomethyl]-4-methylphenol], the aminopeptidase activity was improved 250 times by the substitution of the p-methyl group into p-nitro group. The rate constants were found to be ordered as 1 > 2 >3 (250:10:1), and this order is a decreasing order of the electron-withdrawing effect of the p-substituents of the dinucleating ligands 1(-NO2) > 2(-Cl) > 3(-CH3). (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(03)00119-1