N-1'-ethyl,N-3'-((S)-1-phenylethyl)-(S)-2'H,3H,5'H-spiro[2-benzofuran-1,4'-imidazolidine]-2',3,5'-trione | 1370336-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: N-1'-ethyl,N-3'-((S)-1-phenylethyl)-(S)-2'H,3H,5'H-spiro[2-benzofuran-1,4'-imidazolidine]-2',3,5'-trione
• 英文别名: (3S)-3'-ethyl-1'-[(1S)-1-phenylethyl]spiro[2-benzofuran-3,5'-imidazolidine]-1,2',4'-trione
• CAS: 1370336-84-7
• 化学式: C₂₀H₁₈N₂O₄
• 分子量: 350.374
• InChiKey: DSJNRBFZOXCSOU-RBZFPXEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3,3a,8a-tetrahydro-(3a,8a)-dihydroxy-1-ethyl, 3-((S)-1-phenylethyl)indeno-[1,2-d]-imidazole-2,8-dione 在 sodium periodate 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以42%的产率得到N-1'-ethyl,N-3'-((S)-1-phenylethyl)-(S)-2'H,3H,5'H-spiro[2-benzofuran-1,4'-imidazolidine]-2',3,5'-trione
  参考文献：
  名称：

  Synthesis, resolution and anticonvulsant activity of chiral N-1′-ethyl,N-3′-(1-phenylethyl)-(R,S)-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-trione diastereomers

  摘要：

  Four new N-1', N-3'-disubstituted-2'H, 3H, 5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones bearing a chiral N-3' substituent were synthesized, resolved and their anticonvulsant activity was obtained and determined that the activity was not stereoselective. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.005