(E)-1-fluoro-2-(4-fluorostyryl)benzene | 1261237-34-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1-fluoro-2-(4-fluorostyryl)benzene
• 英文别名: (E)-1-(4-fluorophenyl)-2-(2-fluorophenyl)-ethene；1-fluoro-2-[(E)-2-(4-fluorophenyl)ethenyl]benzene
• CAS: 1261237-34-6
• 化学式: C₁₄H₁₀F₂
• 分子量: 216.23
• InChiKey: KODNEMWTMWYIPG-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氟氯苄 在 sodium hydride 作用下， 以 乙腈 、 苯 为溶剂， 反应 28.0h， 生成 (E)-1-fluoro-2-(4-fluorostyryl)benzene
  参考文献：
  名称：

  Synthesis and biological evaluation of some stilbene derivatives

  摘要：

  Several trans and cis stilbenes with substitution on the olefinic bridge were synthesized and characterized by IR, NMR and mass spectroscopy in an effort to obtain substances that could be more readily formulated. All the synthesized compounds were screened against Molt4/C8, CEM and L1210 cell lines. None of these compounds were endowed with pronounced cytostatic activity. However, Schiff derivatives emerged as cytostatic agents (IC(50): 0.77-10 mu g/ml) that deserve further investigation.

  DOI：

  10.1007/s00044-010-9484-1

文献信息

• [EN] COSMETIC COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS COSMÉTIQUES ET PROCÉDÉS D'UTILISATION
  申请人：STC UNM

  公开号：WO2020112998A1

  公开（公告）日：2020-06-04

  The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFKB and as agonists (activators) ofNrf2. In particular, these compounds show dual activity and it has been discovered that these compounds are particularly useful in the treatment of certain cosmetic applications and in rejuvenating and beautifying skin and other keratinous tissue of a subject in need. Cosmetic compositions and methods of using said compositions in combination with other components are disclosed herein.

  本发明涉及替代的stilbenes和dienones，表现出意外的双重活性，作为NFKB的抑制剂和Nrf2的激动剂。特别是，这些化合物展现了双重活性，已经发现这些化合物在治疗某些化妆品应用以及在使需要的主体的皮肤和其他角质组织恢复活力和美化方面特别有用。本文披露了化妆品组合物以及使用所述组合物与其他成分结合的方法。
• Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes
  作者：Lorraine M. Deck、Lisa J. Whalen、Lucy A. Hunsaker、Robert E. Royer、David L. Vander Jagt

  DOI：10.1016/j.bmc.2017.01.005

  日期：2017.2

  is the issue of selectivity. In the present study, substituted trans stilbenes were identified as activators of Nrf2. These activators of Nrf2 are not highly electrophilic and therefore are unlikely to activate Nrf2 through covalent modification of Keap1. Dose-response studies demonstrated that a range of substituents on either ring of the trans stilbenes, especially fluorine and methoxy substituents

  Nrf2是cap'n'collar转录因子家族的成员，是II期排毒和抗氧化基因以及抗炎和神经保护基因的主要调节剂。在许多慢性疾病中炎症和氧化应激的重要性支持了抗氧化剂Nrf2信号转导可能具有治疗潜力的概念。许多Nrf2激活剂已进入临床试验。Nrf2与它的结合伴侣Keap1结合存在于胞质溶胶中，Keap1是一种富含硫醇的氧化还原传感蛋白。响应于氧化和亲电子应力，Keap1的选定半胱氨酸残基被修饰，从而将Keap1锁定在Nrf2-Keap1复合物中，并使新合成的Nrf2进入细胞核。激活Nrf2的多种化学物质，包括多种天然产物，是亲电试剂，通常通过迈克尔加成来修饰Keap1，从而导致Nrf2激活。作为Keap1的亲电子共价修饰剂的Nrf2活化剂的设计，一个需要关注的问题是选择性问题。在本研究中，替代反式斯蒂芬苯酯被鉴定为Nrf2的激活剂。这些Nrf2激活剂不是高度亲电的，因此不太可能通过Keap
• Metal–Micelle Cooperativity: Phosphine Ligand-Free Ultrasmall Palladium(II) Nanoparticles for Oxidative Mizoroki–Heck-type Couplings in Water at Room Temperature
  作者：Tharique N. Ansari、Jacek B. Jasinski、David K. Leahy、Sachin Handa

  DOI：10.1021/jacsau.0c00087

  日期：2021.3.22

  stems from metal cation−π interactions of the styrene along with transmetalation by the arylboronic acid, followed by insertion and β-H elimination to furnish the coupled product along with the reoxidation of Pd by benzoquinone to complete the catalytic cycle. This method is very mild and sustainable, both in terms of NP synthesis and subsequent catalysis, and shows broad substrate scope while circumventing

  两亲物 PS-750-M 从 Pd(OAc) 2 中生成稳定的、无膦配体且具有催化活性的超小 Pd(II) 纳米粒子 (NPs)，防止它们的沉淀、聚合和氧化态变化。PS-750-M 直接与 Pd(II) NP 表面相互作用，高分辨率质谱和红外光谱证实了它们的高稳定性。NPs 中的 Pd 阳离子很可能被氢氧化物和乙酸根离子结合在一起。纳米颗粒通过 HRTEM 表征，揭示它们的形态和粒度分布，通过 HRMS 和 IR 表征，为 NP-两亲相互作用提供证据。在室温下在水中氧化 Mizoroki-Heck 型偶联的背景下检查了 NP 催化活性。热过滤、热萃取和三相测试表明在胶束界面发生多相催化，而不是在溶液中发生均相催化。NMR研究表明，催化活性源于苯乙烯的金属阳离子-π相互作用以及芳基硼酸的金属转移，然后插入和β-H消除以提供偶联产物以及苯醌对Pd的再氧化以完成催化循环。这种方法在 NP 合成和
• USE OF APPENDED DYES IN OPTICAL DATA STORAGE MEDIA
  申请人：Natarajan Arunkumar

  公开号：US20120052232A1

  公开（公告）日：2012-03-01

  The present disclosure relates to optical media and the formation and use of such media. In certain embodiments the optical media or a composition suitable for such media includes a polymeric matrix or substrate. A dye, such as an energy transfer dye is chemically appended to the polymeric matrix or substrate, such as by one or more covalent bonds.
• Substituted Stilbenes as Inhibitors of NF-kappaB and Activators of Nrf2
  申请人：STC.UNM

  公开号：US20190160021A1

  公开（公告）日：2019-05-30

  The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFκB and as agonists (activators) of Nrf2. In particular, these compounds show dual activity and makes them particularly useful in the treatment of inflammation, including chronic inflammation and a number of related chronic disease states and conditions, including neurological diseases, including Alzheimer's, Alzheimer's prodrome and mild cognitive impairment, and other diseases and conditions, such as Parkinson's disease, depression, bipolar disorders and autism spectrum disorders. Compounds, pharmaceutical compositions and methods of treatment are described.