8-(2-dimethylamino-ethoxy)-chromeno[2,3-b]pyridin-5-one | 54629-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-(2-dimethylamino-ethoxy)-chromeno[2,3-b]pyridin-5-one
• 英文别名: 8-[2-(dimethylamino)ethoxy]chromeno[2,3-b]pyridin-5-one
• CAS: 54629-20-8
• 化学式: C₁₆H₁₆N₂O₃
• 分子量: 284.315
• InChiKey: SIAIDOAOVHABJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-hydroxy-5H-chromeno[2,3-b]pyridin-5-one 以38%的产率得到
  参考文献：
  名称：

  VILLANI F. J.; MANN T. A.; WEFER E. A.; HANNON J.; LARCA L. L.; LANDON M.+, J. MED. CHEM. , 1975, 18, NO 1, 1-8

  摘要：

  DOI：

文献信息

• Benzopyranopyridine derivatives. 1. Aminoalkyl derivatives of the azaxanthenes as bronchodilating agents
  作者：Frank J. Villani、Thomas A. Mann、Elizabeth A. Wefer、Janet Hannon、Louis L. Larca、Mildred J. Landon、William Spivak、Dhiru Vashi、Salvatore Tozzi

  DOI：10.1021/jm00235a001

  日期：1975.1

  The preparation of the four isomeric azaxanthones 3 and a number of their aromatic ring substituted derivatives is described. These ketones were converted into the title compounds which were examined for their biological properties. The most interesting compound in this series, the 1-methyl-4-piperidylidene derivative of 1-azaxanthene, shows the profile of an orally effective potent bronchodilating agent as well as a moderate antihistamine. Biological properties of this compound were compared to a number of antihistamines as well as known bronchodilating agents. Structure-activity relationships are also discussed.