2-<2-Acetyl-hydrazino>-4-<5-nitro-2-furyl>-thiazol | 90324-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2-<2-Acetyl-hydrazino>-4-<5-nitro-2-furyl>-thiazol
• 英文别名: acetic acid N'-[4-(5-nitro-furan-2-yl)-thiazol-2-yl]-hydrazide；N'-[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]acetohydrazide
• CAS: 90324-01-9
• 化学式: C₉H₈N₄O₄S
• 分子量: 268.253
• InChiKey: RUSXMPAKGXFZLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  141
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(2-异亚丙基肼基)-4-(5-硝基-2-呋喃基)噻唑 在 盐酸 作用下， 生成 2-<2-Acetyl-hydrazino>-4-<5-nitro-2-furyl>-thiazol
  参考文献：
  名称：

  4-(5-Nitro-2-furyl)thiazoles^1a

  摘要：

  DOI：

  10.1021/jo01051a053

文献信息

• AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170066759A1

  公开（公告）日：2017-03-09

  The present invention is related to a compound represented by formula (I) wherein R 1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is —N(R 3 )—, —O—, or —S—; Y is ═C(R 4 )—, or ═N—; Z is —N(R 7 )—, —O—, or —S—; R 2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: —(CR 2a R 2b ) n —R 2c , wherein R 2a is each independently a hydrogen atom, halogen, or the like; R 2b is each independently a hydrogen atom, halogen, or the like; R 2a and R 2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R 2a which are attached to the adjacent carbon atoms and/or two of R 2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R 2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3; R 3 and R 7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R 4 and R 5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like; R 6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.
• 4-(5-Nitro-2-furyl)thiazoles^1a
  作者：WILLIAM R. SHERMAN、DONALD E. DICKSON

  DOI：10.1021/jo01051a053

  日期：1962.4