2-Bromo-3-hydroxymethylbenzofuran | 90403-93-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-Bromo-3-hydroxymethylbenzofuran
• 英文别名: 2-Bromo-3-hydroxymethyl benzofuran；(2-bromo-1-benzofuran-3-yl)methanol
• CAS: 90403-93-3
• 化学式: C₉H₇BrO₂
• 分子量: 227.057
• InChiKey: YRYSRLGGOBIUKU-UHFFFAOYSA-N

物化性质

• 沸点：
  332.6±27.0 °C(Predicted)
• 密度：
  1.665±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Bromo-3-hydroxymethylbenzofuran 在 manganese(IV) oxide 、 sodium hydrogensulfide 作用下， 以 甲醇 、 氯仿 、 水 为溶剂， 反应 6.33h， 生成 2-mercaptobenzofuran-3-carbaldehyde
  参考文献：
  名称：

  Condensed heterocycles. 48. Benzo[b]furan mercapto- and selenolaldehydes in the synthesis of bifunctional and complex-forming compounds

  摘要：

  DOI：

  10.1007/bf00960669
• 作为产物：
  描述：

  3-甲基苯并呋喃 在 碳酸氢钠 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.75h， 生成 2-Bromo-3-hydroxymethylbenzofuran
  参考文献：
  名称：

  Method of obtaining 2-bromo-3-benzo(b)furanaldehyde

  摘要：

  DOI：

  10.1007/bf00951108

文献信息

• Compositions and methods for non-invasive imaging of soluble beta-amyloid
  申请人：——

  公开号：US20040223909A1

  公开（公告）日：2004-11-11

  A method for assessing levels of soluble A-beta as an indicator of Alzheimer's disease, and other amyloid-related diseases, in vitro, ex vivo, in vivo, and in situ which employs an imaging agent binds specifically to soluble A-beta and is labeled for detection.

  一种用于评估可溶性A-beta水平作为阿尔茨海默病和其他淀粉样相关疾病的指标的方法，包括体外、体内、外体和原位检测，该方法使用一种成像剂，该成像剂专门结合可溶性A-beta并标记以进行检测。
• DETECTING SOLUBLE A-BETA
  申请人：Tan Hehir Cristina Abucay

  公开号：US20090162280A1

  公开（公告）日：2009-06-25

  Agents, methods, and kits for qualitatively or quantitatively determining the presence of soluble A-beta in source of A-beta are provided, wherein the agents comprise the compound of formula III or the compound of formula III labeled with a signal generator.

  提供了用于定性或定量确定A-beta溶解物在A-beta来源中存在的试剂、方法和试剂盒，其中试剂包括式III的化合物或标记有信号发生器的式III的化合物。
• MYELIN DETECTION USING BENZOFURAN DERIVATIVES
  申请人：Hehir Christina Abucay Tan

  公开号：US20100068140A1

  公开（公告）日：2010-03-18

  The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.

  本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物的方法，用于检测髓鞘并定量测量其在样品中的局部浓度。在一种实施例中，髓鞘检测方法包括确定处于髓鞘相关神经病风险或诊断的受试者，将苯并呋喃化合物或其衍生物经肠外给予受试者，并通过检测样品中的结合来确定受试者的髓鞘化。在另一种实施例中，本发明提供了一种在哺乳动物组织的手术领域中成像髓鞘组织的方法，包括将苯并呋喃化合物或其放射性同位素衍生物接触手术部位，并检测手术部位的结合。在另一种实施例中，本发明提供了一种成像脊髓和脊神经根组织的方法，包括通过肠外给予苯并呋喃化合物的放射性同位素衍生物，并检测脊髓管和椎间孔内的放射性同位素衍生物。本发明还提供了苯并呋喃化合物或其衍生物结合定量的方法。
• Myelin detection using benzofuran derivatives
  申请人：General Electric Company

  公开号：US08114382B2

  公开（公告）日：2012-02-14

  The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.

  本发明涉及使用苯并呋喃化合物或其放射性同位素衍生物的方法来检测髓鞘并量化其在样本中的局部浓度。在一种实施例中，髓鞘检测方法包括识别患有或被诊断患有髓鞘相关神经病变的受试者，将苯并呋喃化合物或其衍生物经肠外途径给予受试者，并通过检测样本中的结合来确定受试者的髓鞘化。在另一种实施例中，本发明提供了一种在哺乳动物组织的手术现场成像髓鞘组织的方法，包括将手术部位与苯并呋喃化合物或其放射性同位素衍生物接触，并检测手术部位的结合。在另一种实施例中，提供了一种成像脊髓和脊神经根组织的方法，包括经肠外途径给予苯并呋喃化合物的放射性同位素衍生物，并检测脊髓管和椎间孔内的放射性同位素衍生物。还提供了苯并呋喃化合物或其衍生物结合定量的方法。
• Condensed heterocycles. 42. Synthesis and some properties of 3-hydroselenobenzo[b]furan-2-carbaldehyde and 2-hydroselenobenzo[b]furan-3-carbaldehyde
  作者：V. P. Litvinov、V. Yu. Mortikov、A. F. Vaisburg

  DOI：10.1007/bf00506386

  日期：1984.9