5-Phenyl-6-(p-methoxy-phenyl)-4-amino-furo<2,3-d>pyrimidin | 14774-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 5-Phenyl-6-(p-methoxy-phenyl)-4-amino-furo<2,3-d>pyrimidin
• 英文别名: 6-(4-methoxy-phenyl)-5-phenyl-furo[2,3-d]pyrimidin-4-ylamine；6-(4-Methoxyphenyl)-5-phenylfuro[2,3-d]pyrimidin-4-amine
• CAS: 14774-66-4
• 化学式: C₁₉H₁₅N₃O₂
• 分子量: 317.347
• InChiKey: FXZGACQGWCUFQC-UHFFFAOYSA-N

物化性质

• 沸点：
  500.7±50.0 °C(Predicted)
• 密度：
  1.271±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-5-(4-甲氧基苯基)-4-苯基呋喃-3-腈 、 formamide 生成 5-Phenyl-6-(p-methoxy-phenyl)-4-amino-furo<2,3-d>pyrimidin
  参考文献：
  名称：

  Temnikova,T.I. et al., Journal of Organic Chemistry USSR (English Translation), 1967, vol. 3, p. 651 - 654

  摘要：

  DOI：

文献信息

• TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX
  申请人：Emert-Sedlak Lori

  公开号：US20110190241A1

  公开（公告）日：2011-08-04

  Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.

  用于抑制HIV-I复制的药物候选物可以针对Src家族激酶（SFK），如与病毒的Nef蛋白相互作用的Hck进行靶向。通过对Nef:SFK复合物中SFK的激酶活性进行测定，鉴定了具有这种抑制活性的化合物。使用激酶测定鉴定的抑制剂的例子包括各种2,3-二氨基喹啉和呋喃[2,3-d]嘧啶。这些创新的抑制剂被发现可以在体外阻止HIV-I病毒的复制。
• Temnikova,T.I. et al., Journal of Organic Chemistry USSR (English Translation), 1967, vol. 3, p. 651 - 654
  作者：Temnikova,T.I. et al.

  DOI：——

  日期：——
• US8541415B2
  申请人：——

  公开号：US8541415B2

  公开（公告）日：2013-09-24
• [EN] TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX<br/>[FR] CIBLAGE D'UN COMPLEXE NEF DE VIH 1/KINASE DE CELLULE HÔTE
  申请人：UNIV PITTSBURGH

  公开号：WO2009139886A2

  公开（公告）日：2009-11-19

  Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3- diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.