3-(naphthylmethyl)imidazolo(5,4-b)pyridine-2-thiol | 255398-19-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(naphthylmethyl)imidazolo(5,4-b)pyridine-2-thiol
• 英文别名: 3-(naphthalen-1-ylmethyl)-1H-imidazo[4,5-b]pyridine-2-thione
• CAS: 255398-19-7
• 化学式: C₁₇H₁₃N₃S
• 分子量: 291.376
• InChiKey: JVSZYSQWDPDRJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Benzimidazole derivative
  申请人：Tsuchiya Naoki

  公开号：US20050267148A1

  公开（公告）日：2005-12-01

  The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

  本发明是一种由以下式（1）表示的硫苯并咪唑衍生物或其医学上可接受的盐，其中所述的硫苯并咪唑衍生物及其医学上可接受的盐具有抑制人体胰蛋白酶的强效活性。因此，它们是潜在的预防和/或治疗剂，可在涉及人体胰蛋白酶的各种疾病中进行临床应用。
• Thiobenzimidazole derivatives
  申请人：Matsumoto Yoshiyuki

  公开号：US20060040976A1

  公开（公告）日：2006-02-23

  The present invention is a thiobenzimidazole derivative represented by the following formula (1) or a medically acceptable salt thereof wherein said thiobenzimidazole derivative and a medically acceptable salt thereof have a potent activity of inhibiting human chymase. Thus, they are potential preventive and/or therapeutic agents clinically applicable to various diseases in which human chymase is involved.

  本发明涉及一种由以下式（1）所表示的硫代苯并咪唑衍生物或其医学上可接受的盐，其中所述的硫代苯并咪唑衍生物及其医学上可接受的盐具有抑制人类胰蛋白酶的强效活性。因此，它们是潜在的预防和/或治疗剂，可在人类胰蛋白酶参与的各种疾病的临床上应用。
• THIOBENZIMIDAZOLE DERIVATIVES
  申请人：TEIJIN LIMITED

  公开号：EP1097926A1

  公开（公告）日：2001-05-09

  Thiobenzimidazole derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof which have a potent human chymase inhibitory activity and, therefore, are usable as clinically applicable preventives and/or remedies for various diseases in which human chymase participates.

  通式（1）代表的硫代苯并咪唑衍生物或其药学上可接受的盐类，具有强效的人类糜蛋白酶抑制活性，因此可作为临床上适用的预防剂和/或治疗人类糜蛋白酶参与的各种疾病的药物。
• US7268145B2
  申请人：——

  公开号：US7268145B2

  公开（公告）日：2007-09-11