1-[2-(Benzotriazol-1-yl)-1,2-bis(3-phenylpiperidin-1-yl)ethyl]benzotriazole | 1360181-54-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[2-(Benzotriazol-1-yl)-1,2-bis(3-phenylpiperidin-1-yl)ethyl]benzotriazole
• 英文别名: 1-[2-(benzotriazol-1-yl)-1,2-bis(3-phenylpiperidin-1-yl)ethyl]benzotriazole
• CAS: 1360181-54-9
• 化学式: C₃₆H₃₈N₈
• 分子量: 582.751
• InChiKey: QCFSPDUZOSESFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(1H-indazol-4-yl)-3-morpholin-4-ylpyrazin-2-amine 、 1-[2-(Benzotriazol-1-yl)-1,2-bis(3-phenylpiperidin-1-yl)ethyl]benzotriazole 在 potassium hydroxide 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.33h， 生成 4-[6-(1H-indazol-4-yl)-3-(3-phenylpiperidin-1-yl)imidazo[1,2-a]pyrazin-8-yl]morpholine
  参考文献：
  名称：

  New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives

  摘要：

  First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.077
• 作为产物：
  描述：

  T406石油添加剂 、 3-苯基哌啶 、 草酸醛 以 乙醇 、 水 为溶剂， 反应 16.0h， 生成 1-[2-(Benzotriazol-1-yl)-1,2-bis(3-phenylpiperidin-1-yl)ethyl]benzotriazole
  参考文献：
  名称：

  New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives

  摘要：

  First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.077

文献信息

• New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives
  作者：Joaquín Pastor、Sonsoles Rodríguez-Arístegui、Ana Isabel Hernández、Carmen Varela、Antonio Salgado、Sonia Martínez

  DOI：10.1016/j.tetlet.2011.12.077

  日期：2012.2

  First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. (C) 2011 Elsevier Ltd. All rights reserved.