(2R,3R,4S)-6-nitro-4-[N-(2,3-dimethylphenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran | 660404-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (2R,3R,4S)-6-nitro-4-[N-(2,3-dimethylphenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran
• 英文别名: (2R,3R,4S)-2-(dimethoxymethyl)-4-[N-(1H-imidazol-2-ylmethyl)-2,3-dimethylanilino]-2-methyl-6-nitro-3,4-dihydrochromen-3-ol
• CAS: 660404-80-8
• 化学式: C₂₅H₃₀N₄O₆
• 分子量: 482.536
• InChiKey: WRTISOPNOLBBOG-JBRSBNLGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (2R,3R,4R)-3,4-dihydro-2-dimethoxymethyl-3,4-epoxy-2-methyl-6-nitro-2H-1-benzopyran 、 2,3-dimethylphenyl-1H-imidazol-2-ylmethylamine 生成 (2R,3R,4S)-6-nitro-4-[N-(2,3-dimethylphenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran
  参考文献：
  名称：

  Benzopyran derivatives substituted with secondary amines including imidazole, their preparation and pharmaceutical compositions containing them

  摘要：

  本发明涉及用次生胺包括咪唑基取代的苯并吡喃衍生物，以及它们的制备和含有它们的药物组合物。本发明在药理学上对治疗癌症、类风湿性关节炎和糖尿病视网膜病具有抗血管生成作用，同时在保护心脏和神经细胞免受缺血再灌注损伤或保护器官方面在药理学上也有用处。

  公开号：

  US07279497B2

文献信息

• PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MACULAR DEGENERATION
  申请人：Yi Kyu-Yang

  公开号：US20140018402A1

  公开（公告）日：2014-01-16

  The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

  本发明提供了一种用于预防或治疗黄斑退化的药物组合物，其包括以含有咪唑等次生胺的苯并吡喃衍生物或其药学上可接受的盐为活性成分。本发明的药物组合物可以以眼药水的形式使用。
• Pharmaceutical composition for preventing or treating macular degeneration
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：US10485786B2

  公开（公告）日：2019-11-26

  The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.

  本发明提供了一种用于预防或治疗黄斑变性的药物组合物，其活性成分包括被包括咪唑在内的仲胺取代的苯并吡喃衍生物或其药学上可接受的盐类。本发明的药物组合物可以滴眼液的形式使用。
• BENZOPYRAN DERIVATIVES SUBSTITUTED WITH SECONDARY AMINES INCLUDING IMIDAZOLE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP1546136B1

  公开（公告）日：2011-10-05
• US7279497B2
  申请人：——

  公开号：US7279497B2

  公开（公告）日：2007-10-09