1-[1-(8-ethoxy-2,2-dimethyl-2H-chromen-6-ylmethyl)-piperidin-4-yl]-1,5-dihydro-imidazo[4,5-c]pyridin-4-one | 1067717-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-[1-(8-ethoxy-2,2-dimethyl-2H-chromen-6-ylmethyl)-piperidin-4-yl]-1,5-dihydro-imidazo[4,5-c]pyridin-4-one
• 英文别名: 1-[1-(8-ethoxy-2,2-dimethyl-2H-chromen-6-ylmethyl)-piperidin-4-yl]-l,5-dihydro-imidazo[4,5-c]pyridin-4-one；1-[1-[(8-ethoxy-2,2-dimethylchromen-6-yl)methyl]piperidin-4-yl]-5H-imidazo[4,5-c]pyridin-4-one
• CAS: 1067717-80-9
• 化学式: C₂₅H₃₀N₄O₃
• 分子量: 434.538
• InChiKey: PHGHBJQECZJQLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  68.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BENZOIMIDAZOLE, TETRAHYDRO-QUINOXALINE, BENZOTRIAZOLE, DIHYDRO-IMIDAZO[4,5-c] PYRIDINONE AND DIHYDRO-ISOINDOLONE DERIVATIVES
  申请人：Bleicher Konrad

  公开号：US20080249101A1

  公开（公告）日：2008-10-09

  This invention relates to compounds of the formula wherein A, R 1 to R 3 are as defined in the specification and G is benzoimidazole, quinoxaline, benzotriazole, dihydro-imidazo[4,5-c]pyridine and dihydro-isoindolone group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

  这项发明涉及以下式的化合物 其中A，R1至R3如规范中所定义，G为苯并咪唑，喹喔啉，苯并三唑，二氢咪唑[4,5-c]吡啶和二氢异吲哚酮基团，如规范中所定义，并其药学上可接受的盐。该发明还涉及含有这种化合物的药物组合物，以及用于制备它们的方法和它们用于治疗和/或预防与调节SST受体亚型5相关的疾病。
• 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2142528B1

  公开（公告）日：2010-07-07
• US7799806B2
  申请人：——

  公开号：US7799806B2

  公开（公告）日：2010-09-21