| 1357641-15-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1357641-15-6
• 化学式: C₂₇H₃₇N₃O₅
• 分子量: 483.608
• InChiKey: ZMJDYVBEASXUEV-LJKQEARRSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 DCE 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Build/Couple/Pair Strategy for the Synthesis of Stereochemically Diverse Macrolactams via Head-to-Tail Cyclization

  摘要：

  A build/couple/pair (B/C/P) strategy was employed to generate a library of 7936 stereochernically diverse 12-membered macrolactams. All 8 stereoisomers of a common linear amine precursor were elaborated to form the corresponding 8 stereoisomers of two regioisomeric macrocyclic scaffolds via head-to-tail cyclization. Subsequently,these 16 scaffolds were further diversified via capping of two amine functionalities on SynPhase Lanterns. Reagents used for solid-phase diversification were selected using a sparse matrix design strategy with the aim of maximizing coverage of chemical space while adhering to a preset range of physicochemical properties.

  DOI：

  10.1021/co200161z