(S)-1-(4-methylphenyl)dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-dione | 1020410-89-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (S)-1-(4-methylphenyl)dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-dione
• 英文别名: (7aS)-1-(4-methylphenyl)-3,6,7,7a-tetrahydropyrrolo[1,2-a]imidazole-2,5-dione
• CAS: 1020410-89-2
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: IABKCVSRMMSOMZ-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1H-吡咯并[1,2-a]咪唑-2,5(3H,6H)-二酮,二氢-,(R)- 、 4-碘甲苯 在 copper(l) iodide 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以47%的产率得到(S)-1-(4-methylphenyl)dihydro-1H-pyrrolo[1,2-a]imidazole-2,5(3H,6H)-dione
  参考文献：
  名称：

  WO2008/58988

  摘要：

  公开号：

文献信息

• Pyrrolo[1,2-A]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
  申请人：Neurotune AG

  公开号：US07973066B2

  公开（公告）日：2011-07-05

  The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.

  本发明公开了使用式（I）化合物来治疗和/或预防化疗引起的周围神经毒性（CIPN）的方法。该发明包括药物组合物，其中式（I）化合物与抗癌剂混合。还提供了一种改进的抗癌治疗方法，可以减少与CIPN相关的副作用。
• Pyrrolo[1,2-a]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents
  申请人：NIKEM RESEARCH S.R.L.

  公开号：EP1925304A1

  公开（公告）日：2008-05-28

  The use of a compound of formula (I) is disclosed in treating and/or preventing chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.

  本发明公开了式（I）化合物在治疗和/或预防化疗诱导的周围神经毒性（CIPN）中的用途。本发明包括药物组合物，其中式（I）化合物与抗癌剂混合存在。本发明还提供了一种可减少 CIPN 相关副作用的改良抗癌疗法。
• PYRROLOY[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS
  申请人：Neurotune AG

  公开号：EP2094265A1

  公开（公告）日：2009-09-02
• PYRROLO[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS
  申请人：Farina Carlo

  公开号：US20100062077A1

  公开（公告）日：2010-03-11

  The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.
• US7973066B2
  申请人：——

  公开号：US7973066B2

  公开（公告）日：2011-07-05