N-(2-cyclohexylethyl)naphthalen-1-amine | 1467077-63-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-cyclohexylethyl)naphthalen-1-amine
• CAS: 1467077-63-9
• 化学式: C₁₈H₂₃N
• 分子量: 253.387
• InChiKey: VZONSTOJQRCJGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-(ethylamino)-4-methyl-2-nitrosophenol hydrochloride 、 N-(2-cyclohexylethyl)naphthalen-1-amine 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以93%的产率得到N-(5-((2-cyclohexylethyl)amino)-10-methyl-9H-benzo[a]phenoxazin-9-ylidene) ethanaminium chloride
  参考文献：
  名称：

  Ultrasound promoted synthesis of Nile Blue derivatives

  摘要：

  Ultrasound irradiation was used for the first time towards the synthesis of new Nile Blue related benzo[a]phenoxazinium chlorides possessing isopentylamino, (2-cyclohexylethyl)amino and phenethylamino groups at 5-position of the heterocyclic system. The efficacy of sonochemistry was investigated with some of our earlier reported synthesis of benzo[a]phenoxazinium chlorides. This newer protocol proved competent in terms of reaction times and enhanced yields. Photophysical studies carried out in ethanol, water and simulated physiological conditions, revealed that emission maxima occurred in the range 644-656 nm, with high fluorescent quantum yields. Other attractive feature exhibited by these materials includes good thermal stability. These properties might be useful in the development of fluorescent probes for biotechnology. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2013.05.010
• 作为产物：
  描述：

  2-环己基溴乙烷 、 1-萘胺 以 乙醇 为溶剂， 生成 N-(2-cyclohexylethyl)naphthalen-1-amine
  参考文献：
  名称：

  NIR探针在苯并[ a ]吩恶嗪的5和9位氨基上具有脂族，芳族和氯化末端的合成，光物理特性和光稳定性研究

  摘要：

  一系列新的苯并[ a]合成了具有在9位上具有3-氯丙基，在5位上为末端的异丙基，环己基和苯基的单和二取代胺的]苯恶嗪氯化物。在无水乙醇和水溶液中进行光物理研究。发现5-氨基位置的末端影响酸碱平衡。发现2-位羟基官能团的存在引入了另一种碱性形式，该碱性形式与干燥乙醇溶液中的阳离子酸形式处于平衡状态。还研究了这些化合物在不同介质中的光稳定性，并在模型生物膜中观察到了对光漂白的高抵抗力。在蛋白质中，在1小时30分钟内会发生20％的中等光漂白，

  DOI：

  10.1016/j.dyepig.2016.04.049

文献信息

• Ultrasound promoted synthesis of Nile Blue derivatives
  作者：B. Rama Raju、Diogo M.F. Sampaio、M.M. Silva、Paulo J.G. Coutinho、M. Sameiro T. Gonçalves

  DOI：10.1016/j.ultsonch.2013.05.010

  日期：2014.1

  Ultrasound irradiation was used for the first time towards the synthesis of new Nile Blue related benzo[a]phenoxazinium chlorides possessing isopentylamino, (2-cyclohexylethyl)amino and phenethylamino groups at 5-position of the heterocyclic system. The efficacy of sonochemistry was investigated with some of our earlier reported synthesis of benzo[a]phenoxazinium chlorides. This newer protocol proved competent in terms of reaction times and enhanced yields. Photophysical studies carried out in ethanol, water and simulated physiological conditions, revealed that emission maxima occurred in the range 644-656 nm, with high fluorescent quantum yields. Other attractive feature exhibited by these materials includes good thermal stability. These properties might be useful in the development of fluorescent probes for biotechnology. (C) 2013 Elsevier B.V. All rights reserved.
• Synthesis, photophysical characterisation and photostability studies of NIR probes with aliphatic, aromatic and chlorinated terminals in 5- and 9-amino positions of benzo[ a ]phenoxazines
  作者：B. Rama Raju、Marcello M.T. Carvalho、Maria Inês P.S. Leitão、Paulo J.G. Coutinho、M. Sameiro T. Gonçalves

  DOI：10.1016/j.dyepig.2016.04.049

  日期：2016.9

  m chlorides possessing mono and disubstituted amines with 3-chloropropyl groups at the 9-position, isopropyl, cyclohexyl and phenyl groups as terminals at 5-postion was synthesised. Photophysical studies were performed in dry ethanol and aqueous solutions. The terminals at the 5-amino position were found to influence the acid-base equilibrium. The presence of hydroxyl functionality at 2-position was

  一系列新的苯并[ a]合成了具有在9位上具有3-氯丙基，在5位上为末端的异丙基，环己基和苯基的单和二取代胺的]苯恶嗪氯化物。在无水乙醇和水溶液中进行光物理研究。发现5-氨基位置的末端影响酸碱平衡。发现2-位羟基官能团的存在引入了另一种碱性形式，该碱性形式与干燥乙醇溶液中的阳离子酸形式处于平衡状态。还研究了这些化合物在不同介质中的光稳定性，并在模型生物膜中观察到了对光漂白的高抵抗力。在蛋白质中，在1小时30分钟内会发生20％的中等光漂白，