trans-3,3',5,5'-tetrakis[(4-carboxyphenyl)methoxy]stilbene | 748766-13-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: trans-3,3',5,5'-tetrakis[(4-carboxyphenyl)methoxy]stilbene
• 英文别名: 4-[[3-[(E)-2-[3,5-bis[(4-carboxyphenyl)methoxy]phenyl]ethenyl]-5-[(4-carboxyphenyl)methoxy]phenoxy]methyl]benzoic acid
• CAS: 748766-13-4
• 化学式: C₄₆H₃₆O₁₂
• 分子量: 780.785
• InChiKey: NXMYRQJSIMFLMN-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  58
• 可旋转键数：
  18
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  186
• 氢给体数：
  4
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Diethyl 2-[[4-amino-5-[(1,5-diethoxy-1,5-dioxopentan-2-yl)amino]-5-oxopentanoyl]amino]pentanedioate 、 trans-3,3',5,5'-tetrakis[(4-carboxyphenyl)methoxy]stilbene 在 1-羟基苯并三唑 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.33h， 以47%的产率得到
  参考文献：
  名称：

  Stilbene-cored poly(glutamate) dendrimers

  摘要：

  A new class of photoresponsive poly(glutamate) dendrimers based on a stilbene core unit was successfully synthesized. The core stilbene was used to probe the polarity inside the dendrimer based on changes in the absorption and fluorescence spectra under various solvent conditions. Upon acidification of a solution of one of the dendrimers, wG1, the absorption band decreased with red-shift and the fluorescence band decreased with blue-shift, indicating that the -CO2- groups at dendrimer periphery were protonated, resulting in shrinking of the dendrimer via hydrophobic interactions, and the inside of the dendrimer became more hydrophobic than under neutral pH conditions. In addition, the core stilbene unit underwent photoisomerization to give the cis-isomer with concomitant structural change in the poly(glutamate) dendrimer. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.004