2-(4-bromo-2-fluoro-phenylamino)-4-oxo-6,7,8,9-tetrahydro-4H-quinolizine-1-carboxylic acid methoxy amide | 1193487-50-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹嗪类
• 英文名称: 2-(4-bromo-2-fluoro-phenylamino)-4-oxo-6,7,8,9-tetrahydro-4H-quinolizine-1-carboxylic acid methoxy amide
• 英文别名: 2-(4-bromo-2-fluoroanilino)-N-methoxy-4-oxo-6,7,8,9-tetrahydroquinolizine-1-carboxamide
• CAS: 1193487-50-1
• 化学式: C₁₇H₁₇BrFN₃O₃
• 分子量: 410.243
• InChiKey: YNUXLKCMCHUOPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Heterocyclic Compounds as MEK Inhibitors
  申请人：Chikkanna Dinesh

  公开号：US20090275606A1

  公开（公告）日：2009-11-05

  The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.

  本发明涉及公式I的化合物和药用盐。这些化合物可以作为潜在的MEK抑制剂，用于治疗癌症和炎症等过度增殖性疾病。本发明还揭示了其制备方法。
• HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS
  申请人：Novartis AG

  公开号：EP2421612A1

  公开（公告）日：2012-02-29
• [EN] HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES COMME INHIBITEURS DE MEK
  申请人：NOVARTIS AG

  公开号：WO2010121646A1

  公开（公告）日：2010-10-28

  The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.