5,6-dimethyl-2-chloro-4-(1-methyl-7-fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine | 269402-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 5,6-dimethyl-2-chloro-4-(1-methyl-7-fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine
• 英文别名: 2-(2-chloro-5,6-dimethylpyrimidin-4-yl)-7-fluoro-1-methyl-3,4-dihydro-1H-isoquinoline
• CAS: 269402-45-1
• 化学式: C₁₆H₁₇ClFN₃
• 分子量: 305.782
• InChiKey: DBAWLSYCBGTLIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：YUHAN CORPORATION, LTD.

  公开号：EP1131312A1

  公开（公告）日：2001-09-12
• US6545008B1
  申请人：——

  公开号：US6545008B1

  公开（公告）日：2003-04-08
• [EN] NOVEL PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX DERIVES DE PYRIMIDINE ET LEURS PROCEDES DE PREPARATION
  申请人：YUHAN CORP

  公开号：WO2000029403A1

  公开（公告）日：2000-05-25

  The present invention relates to novel pyrimidine derivatives and pharmaceutically acceptable non-toxic salts thereof which possess an excellent inhibitory activity against gastric acid secretion, a pharmaceutical composition containing the same as an active ingredient, and a process for the preparation thereof.