5-carboxamido-4-isopropyl-2,3-dimethoxy-6,7-dimethyl-1,8-naphtholactone | 1256722-98-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-carboxamido-4-isopropyl-2,3-dimethoxy-6,7-dimethyl-1,8-naphtholactone
• CAS: 1256722-98-1
• 化学式: C₁₉H₂₁NO₅
• 分子量: 343.379
• InChiKey: FGFOZXFOUGMOHK-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  氯磺酰异氰酸酯 、 dihydro-5-(2-isopropyl-3,4-dimethoxyphenyl)-3,4-dimethyl-2-furanone 在 水 作用下， 以 二氯甲烷 、 乙醇 为溶剂， 反应 25.0h， 以10%的产率得到4-isopropyl-2,3-dimethoxy-6,7-dimethyl-1,8-naphtholactone
  参考文献：
  名称：

  Synthesis of hemigossypol and its derivatives

  摘要：

  Hemigossypol (3), a sesquiterpene natural product, was previously isolated from Gossypium barbadense and was shown to display improved anti-furgal activity compared to gossypol (1), the disesquiterpene chiller of hemigossypol (3). Gossypol exhibits multiple biological activities. In order to study whether hemigossypol and its derivatives retain the various bioactivities of gossypol, we developed a short and convenient synthetic scheme to synthesize hemigossypol. This is the first de novo synthesis of this natural product. In addition derivatives of hemigossypol with various 2,5-alkyl substituents were synthesized. Modification of the synthetic scheme also afforded the natural product hemigossylic lactone (4) and its 2,5-substituted derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.089