3'-Methylfluoran | 30982-74-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3'-Methylfluoran
• 英文别名: 3'-Methylspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 30982-74-2
• 化学式: C₂₁H₁₄O₃
• 分子量: 314.34
• InChiKey: XSAFADZFIMENEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES
  申请人：CHANG Christopher J.

  公开号：US20120329085A1

  公开（公告）日：2012-12-27

  The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。
• Fluorogenic/Fluorescent Probes Derivative from Sulfoxanthene, and Use Thereof
  申请人：bioMérieux

  公开号：US20160146814A1

  公开（公告）日：2016-05-26

  The invention relates to fluorescent/fluorogenic probes of formula (I″) or (II″): wherein Z is chosen between: —NH 2 and —OH, or in the fluorescence quencher group consisting of: —NO 2 ; —N═N—R 1 ; R 1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R 2 ; —O—P(O)(OR 2 )(OR 2 ′) and —O—S(O) 2 —R 2 ; R 2 and R 2 ′ being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and R a , R b , R c , R d and R e being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity. It also relates to the use of these fluorescent/fluorogenic probes, for the detection of an enzyme activity, notably in order to identify/discriminate microorganisms in function of their ability to express particular enzyme activities.

  该发明涉及式(I″)或(II″)的荧光/荧光探针： 其中Z在以下选项中选择：—NH2和—OH，或者在荧光猝灭剂基团中选择：—NO2；—N═N—R1；其中R1是任何不遮挡相应偶氮键的有机基团；—NHCO-Pept.；Pept.是肽残基或任何不遮挡相应酰胺键的有机基团；—O-Glyc.；Glyc.是不遮挡相应糖苷键的寡糖苷残基；—O—C(O)—R2；—O—P(O)(OR2)(OR2′)和—O—S(O)2—R2；其中R2和R2′独立地是氢原子或不遮挡相应酯键的有机基团；以及Ra、Rb、Rc、Rd和Re独立地是氢原子或任何不遮挡相应芳基醚键的有机基团，以便不阻止其可能被髓过氧化酶活性水解。 该发明还涉及这些荧光/荧光探针的用途，用于检测酶活性，特别是为了根据微生物表达特定酶活性的能力来识别/区分微生物。
• Loaded latex optical molecular imaging probes
  申请人：Leon Jeffrey W.

  公开号：US20080181965A1

  公开（公告）日：2008-07-31

  The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.

  本发明涉及一种载荷乳胶颗粒，该乳胶材料由以下式表示的混合物制成：(X)m-(Y)n-(Z)o-(W)p，其中Y至少是一种具有至少两个乙烯不饱和化学官能团的单体；Z至少是一种聚乙二醇马克蒙单体，其平均分子量在300至10,000之间；W是与X、Y或Z不同的乙烯单体；X至少是一种水不溶性、含有烷氧基乙烯的单体；m、n、o和p分别是每种单体的重量百分比。该颗粒可以装载荧光染料。
• OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE
  申请人：CORRY Schuyler Boon

  公开号：US20090047692A1

  公开（公告）日：2009-02-19

  The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.

  本发明涉及一种酶底物化合物，经过与该酶的反应后提供可检测的响应，例如光学可检测响应。特别是，这些化合物在检测样品中β-内酰胺酶的存在方面具有实用性。除了这些化合物，还揭示了一种分析样品中β-内酰胺酶存在的方法，例如，作为包括编码β-内酰胺酶的核酸序列的表达的指示器。还揭示了包括上述化合物和其他组分的试剂盒，例如细胞、抗体、β-内酰胺酶或使用这些组分进行检测的说明。
• Chromogenic mixtures
  申请人：MOORE BUSINESS FORMS, INC.

  公开号：EP0201225B1

  公开（公告）日：1990-07-04