1-Nitro-2-propyloxy-naphthalin | 92029-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Nitro-2-propyloxy-naphthalin
• 英文别名: (1-nitro-[2]naphthyl)-propyl ether；(1-Nitro-[2]naphthyl)-propyl-aether；1-nitro-2-propoxynaphthalene
• CAS: 92029-34-0
• 化学式: C₁₃H₁₃NO₃
• 分子量: 231.251
• InChiKey: WJAXQOASPTZREI-UHFFFAOYSA-N

物化性质

• 熔点：
  85-85.5 °C
• 沸点：
  379.6±17.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  52.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-Nitro-2-propyloxy-naphthalin 在 盐酸 、 锌 作用下， 生成 1-(2-Propoxy-[1]naphthylazo)-[2]naphthol
  参考文献：
  名称：

  Pancytopenia after Removal of Copper from Total Parenteral Nutrition

  摘要：

  Patients who develop cholestatic jaundice during chronic total parenteral nutrition (TPN) can develop significant hematologic complications due to hypocupremia if copper supplementation is withheld. A 36‐year‐old female with short bowel syndrome developed progressive liver dysfunction 6 months after initiation of TPN. Trace elements were omitted from her TPN because of cholestasis and persistent hyperbilirubinemia. Despite chronic diarrhea, absorption of some dietary copper was anticipated from her oral diet. Fifteen months later, the patient became red cell transfusion dependent, and her neutrophil and platelet counts steadily declined. After 19 months of receiving TPN without trace elements, her serum copper level was 25 μg/dL (normal: 70 to 155 μg/dL). Provision of trace elements for 2 months was associated with increased serum copper, neutrophil and platelet counts and independence from red cell transfusions. When the serum copper level reached 186 μg/dL, copper supplementation was discontinued. Over the next 3 months, serum copper level fell to 10 μg/dL, neutrophil and platelet counts fell precipitously, and red cell transfusions were resumed. Once again, copper, neutrophil and platelet levels promptly rebounded with parenteral copper supplementation. Although anemia and neutropenia are well‐recognized hematologic consequences of copper deficiency, thrombocytopenia rarely has been reported. This is the first report of pancytopenia secondary to TPN‐related copper deficiency in which the association was confirmed when hypocupremia recurred. (Journal of Parenteral and Enteral Nutrition 24:361–366, 2000)

  DOI：

  10.1177/0148607100024006361
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 1-Nitro-2-propyloxy-naphthalin
  参考文献：
  名称：

  Pancytopenia after Removal of Copper from Total Parenteral Nutrition

  摘要：

  Patients who develop cholestatic jaundice during chronic total parenteral nutrition (TPN) can develop significant hematologic complications due to hypocupremia if copper supplementation is withheld. A 36‐year‐old female with short bowel syndrome developed progressive liver dysfunction 6 months after initiation of TPN. Trace elements were omitted from her TPN because of cholestasis and persistent hyperbilirubinemia. Despite chronic diarrhea, absorption of some dietary copper was anticipated from her oral diet. Fifteen months later, the patient became red cell transfusion dependent, and her neutrophil and platelet counts steadily declined. After 19 months of receiving TPN without trace elements, her serum copper level was 25 μg/dL (normal: 70 to 155 μg/dL). Provision of trace elements for 2 months was associated with increased serum copper, neutrophil and platelet counts and independence from red cell transfusions. When the serum copper level reached 186 μg/dL, copper supplementation was discontinued. Over the next 3 months, serum copper level fell to 10 μg/dL, neutrophil and platelet counts fell precipitously, and red cell transfusions were resumed. Once again, copper, neutrophil and platelet levels promptly rebounded with parenteral copper supplementation. Although anemia and neutropenia are well‐recognized hematologic consequences of copper deficiency, thrombocytopenia rarely has been reported. This is the first report of pancytopenia secondary to TPN‐related copper deficiency in which the association was confirmed when hypocupremia recurred. (Journal of Parenteral and Enteral Nutrition 24:361–366, 2000)

  DOI：

  10.1177/0148607100024006361