(4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-methyl-amine | 14015-20-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-methyl-amine
• 英文别名: (Chlor-methoxy-[1,3,5]triazin-2-yl)-methyl-amin；6-chloro-4-methoxy-N-methyl-1,3,5-triazin-2-amine；4-chloro-6-methoxy-N-methyl-1,3,5-triazin-2-amine；2-Chlor-6-methoxy-4-methylamino-1,3,5-triazin
• CAS: 14015-20-4
• 化学式: C₅H₇ClN₄O
• 分子量: 174.59
• InChiKey: SPJOTIACNJIMEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-methyl-amine 、 sodium β-(diethyalmino)ethylmercaptide 以 苯 为溶剂， 反应 3.0h， 生成 4-[2-(diethylamino)ethylsulfanyl]-6-methoxy-N-methyl-1,3,5-triazin-2-amine
  参考文献：
  名称：

  Synthesis and curare-like activity of β-(trialkylammonium)ethyl esters of thiocyanuric acid

  摘要：

  DOI：

  10.1007/bf00766362
• 作为产物：
  描述：

  2,4-二氯-6-(甲基氨基)-1,3,5-三嗪 、 sodium methylate 以 甲醇 为溶剂， 生成 (4-chloro-6-methoxy-[1,3,5]triazin-2-yl)-methyl-amine
  参考文献：
  名称：

  Dimethoxypyrimidines as Novel Herbicides. Part 1. Synthesis and Herbicidal Activity of Dimethoxyphenoxyphenoxypyrimidines and Analogues

  摘要：

  A number of 6-(4-phenoxyphenoxy)pyrimidines and triazines were synthesized and their herbicidal activity was measured. Compounds with the methoxy groups at the 2- and 4-positions on the pyrimidine and triazine rings exhibited high herbicidal activity. Introduction of a substituent into the 5-position of the pyrimidine ring diminished the activity. In the phenoxyphenoxy substructure at the 6-position, the central ether bond can be replaced by a methylene group without loss of activity. The optimum substituent on the terminal phenyl ring was 3-trifluoromethyl. The compounds showed a strong Hill reaction inhibition, but unfortunately showed poor selectivity between weeds and crops.

  DOI：

  10.1002/(sici)1096-9063(199606)47:2<103::aid-ps396>3.0.co;2-z

文献信息

• Substituted heterocyclic compounds and methods of use
  申请人：Andersen Lyn Denise

  公开号：US20060069110A1

  公开（公告）日：2006-03-30

  The present invention relates to pyridines, pyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

  本发明涉及吡啶、嘧啶及其衍生物，以及其药用盐。还包括一种治疗炎症、类风湿关节炎、帕盖特病、骨质疏松症、多发性骨髓瘤、葡萄膜炎、急性或慢性骨髓性白血病、胰岛素β细胞破坏、骨关节炎、类风湿脊柱炎、痛风性关节炎、炎症性肠病、成人呼吸窘迫综合征（ARDS）、牛皮癣、克罗恩病、过敏性鼻炎、溃疡性结肠炎、过敏反应、接触性皮炎、哮喘、肌肉退化、虚弱、赖特氏综合征、I型糖尿病、II型糖尿病、骨吸收性疾病、移植物抗宿主反应、阿尔茨海默病、中风、心肌梗塞、缺血再灌注损伤、动脉粥样硬化、脑外伤、多发性硬化、脑疟疾、败血症、脓毒性休克、中毒性休克综合征、发热、由HIV-1、HIV-2、HIV-3、巨细胞病毒（CMV）、流感病毒、腺病毒、疱疹病毒或带状疱疹感染引起的肌肉疼痛的方法，包括向哺乳动物施用上述化合物的有效量。
• POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS
  申请人：Salvemini Daniela

  公开号：US20080318917A1

  公开（公告）日：2008-12-25

  Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide, dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.

  化合物和利用化合物的方法，包括将超氧化物歧化酶类似物共价连接到聚乙二醇中。还提供了制备超氧化物歧化酶类似物共价连接到聚乙二醇的方法，其中包括将活化聚乙二醇与超氧化物歧化酶类似物反应，或者将超氧化物歧化酶类似物与活化聚乙二醇反应。还提供了一种方法，用于预防或治疗超氧阴离子参与的疾病或紊乱，包括向需要治疗的受体注射含有超氧化物歧化酶类似物共价连接到聚乙二醇的化合物的治疗有效剂量。还提供了确定化合物安全性和有效性的方法。确定安全性和有效性的方法可以包括在实验动物和人类中进行的方法。
• REVERSIBLE PEGYLATED DRUGS
  申请人：Yeda Research and Development Co., Ltd.

  公开号：US20150057219A1

  公开（公告）日：2015-02-26

  Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of the scaffold Fmoc or FMS structure that is highly sensitive to bases and is removable under physiological conditions. The drugs are preferably drugs containing an amino group, most preferably peptides and proteins of low or medium molecular weight. Similar molecules are provided wherein a protein carrier or another polymer carrier replaces the PEG moiety.

  可逆的聚乙二醇化药物是通过对所选药物的游离功能基团（包括氨基，羟基，巯基，磷酸酯和/或羧基）进行衍生化，使用对轻微碱性条件敏感的基团（如9-芴甲氧羰基（Fmoc）或2-磺酸基-9-芴甲氧羰基（FMS）），然后将PEG基团附着在该基团上。在这些聚乙二醇化药物中，PEG基团和药物残基不直接链接在一起，而是两个残基链接到高度敏感于碱性且可在生理条件下去除的Fmoc或FMS结构的不同位置。这些药物最好是含有氨基基团的药物，特别是低分子量或中分子量的肽和蛋白质。类似的分子也可用蛋白质载体或其他聚合物载体代替PEG基团。
• Hofmann, Chemische Berichte, 1885, vol. 18, p. 2773
  作者：Hofmann

  DOI：——

  日期：——
• MARTYNOV, I. V.;KRUGLYAK, YU. L.;GRUZDEVA, V. L.;LEJBOVSKAYA, G. A.;SHITO+, XIM.-FARMATS. ZH., 25,(1991) N, S. 38-40
  作者：MARTYNOV, I. V.、KRUGLYAK, YU. L.、GRUZDEVA, V. L.、LEJBOVSKAYA, G. A.、SHITO+

  DOI：——

  日期：——