7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridine;hydrate;hydrochloride | 2102723-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridine;hydrate;hydrochloride
• CAS: 2102723-14-6
• 化学式: C8H10BrClN2O2
• 分子量: 281.53
• InChiKey: AYSMVISBWCVULG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.9
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING BOROXINE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS D'AZAINDOLE HALOGÉNÉS FAISANT APPEL À LA BOROXINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016100625A1

  公开（公告）日：2016-06-23

  A process for preparing halogenated azaindole compounds makes use of stable reagents including a brominating reagent, a boroxine and a sulfonic anhydride to enhance the selectivity and yield of the final product. In addition, the process is associated with various other advantages, including the ability to recycle reagents, cost reduction, and improved manufacturability.

  一种制备卤代氮吲哚化合物的过程利用稳定试剂，包括溴化试剂、硼氧化物和磺酸酐，以增强最终产品的选择性和产量。此外，该过程还具有各种其他优点，包括能够回收试剂、降低成本和改善可制造性。
• [EN] A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING PYBROP<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS D'AZA-INDOLE HALOGÉNÉ EN UTILISANT DU PYBROP
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016100651A1

  公开（公告）日：2016-06-23

  A process for preparing halogenated azaindole compounds makes use of a brominating agent PyBroP, together with a dehydrating agent BSA to enhance the selectivity and improve the yield of the final product which is a piperazine prodrug useful as an antiviral.

  制备卤代氮杂吲哚化合物的方法利用溴化剂PyBroP，结合脱水剂BSA，以增强选择性并提高最终产物的产率，该产物是一种对抗病毒有用的哌嗪前药。
• [EN] A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING BOROXINE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS D'AZA-INDOLE HALOGÉNÉ AU MOYEN D'UNE BOROXINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2016100633A1

  公开（公告）日：2016-06-23

  A process for preparing halogenated azaindole compounds makes use of stable reagents including a brominating reagent, a boroxine and a sulfonic anhydride to enhance the selectivity and yield of the final product. In addition, the process is associated with various other advantages, including the ability to recycle reagents, cost reduction, and improved manufacturability.

  一种制备卤代氮杂吲化合物的工艺利用稳定试剂，包括溴化试剂、硼氧化物和磺酸酐，以增强最终产物的选择性和产率。此外，该工艺还具有其他各种优点，包括能够回收试剂、降低成本和提高可制造性。
• A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING BOROXINE
  申请人：VIIV HEALTHCARE UK (NO. 4) LIMITED

  公开号：EP3233853A1

  公开（公告）日：2017-10-25
• A PROCESS FOR PREPARING HALOGENATED AZAINDOLE COMPOUNDS USING PYBROP
  申请人：VIIV HEALTHCARE UK (NO. 4) LIMITED

  公开号：EP3233856A1

  公开（公告）日：2017-10-25