(R)-6-tert-butyldiphenylsilyloxy-2-methyl-2-heptene | 1073630-49-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (R)-6-tert-butyldiphenylsilyloxy-2-methyl-2-heptene
• 英文别名: (+)-tert-butyl{[1,5-dimethylhex-4-en-1-yl]oxy}diphenylsilane；tert-butyl-[(2R)-6-methylhept-5-en-2-yl]oxy-diphenylsilane
• CAS: 1073630-49-5
• 化学式: C₂₄H₃₄OSi
• 分子量: 366.619
• InChiKey: YTIIVKPYVSTQCH-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-6-tert-butyldiphenylsilyloxy-2-methyl-2-heptene 在 臭氧 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 22.5h， 生成 (3RS,6R)-6-tert-butyldiphenylsilyloxyhept-1-en-3-ol
  参考文献：
  名称：

  A Chemoenzymatic Synthesis of Hept-6-ene-2,5-diol Stereomers: Application to Asymmetric Synthesis of Decarestrictine L, Pyrenophorol, and Stagonolide E

  摘要：

  The stereomers of hept-6-ene-2,5-diol derivatives were conceived as useful chiral intermediates and were synthesized starting from sulcatol using two lipase-catalyzed acylation reactions as the key steps. The versatility of the intermediates was demonstrated by converting them to the titled tetrahydropyran, macrolide, and macrodiolide compounds using standard synthetic protocols.

  DOI：

  10.1021/jo5012575
• 作为产物：
  描述：

  6-甲基-5-庚烯-2-醇 在 咪唑 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 作用下， 以 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 9.83h， 生成 (R)-6-tert-butyldiphenylsilyloxy-2-methyl-2-heptene
  参考文献：
  名称：

  A Chemoenzymatic Synthesis of Hept-6-ene-2,5-diol Stereomers: Application to Asymmetric Synthesis of Decarestrictine L, Pyrenophorol, and Stagonolide E

  摘要：

  The stereomers of hept-6-ene-2,5-diol derivatives were conceived as useful chiral intermediates and were synthesized starting from sulcatol using two lipase-catalyzed acylation reactions as the key steps. The versatility of the intermediates was demonstrated by converting them to the titled tetrahydropyran, macrolide, and macrodiolide compounds using standard synthetic protocols.

  DOI：

  10.1021/jo5012575

文献信息

• Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof
  申请人：Lampe Thomas

  公开号：US20090318475A1

  公开（公告）日：2009-12-24

  The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.

  本申请涉及新颖的、非环式取代的呋噻嘧啶衍生物，其生产方法，它们用于治疗和/或预防疾病以及用于生产治疗和/或预防疾病的药物制剂，特别是用于治疗和/或预防心血管疾病。
• A Chemoenzymatic Synthesis of Hept-6-ene-2,5-diol Stereomers: Application to Asymmetric Synthesis of Decarestrictine L, Pyrenophorol, and Stagonolide E
  作者：Sucheta Chatterjee、Sneha Ghadigaonkar、Payel Sur、Anubha Sharma、Subrata Chattopadhyay

  DOI：10.1021/jo5012575

  日期：2014.9.5

  The stereomers of hept-6-ene-2,5-diol derivatives were conceived as useful chiral intermediates and were synthesized starting from sulcatol using two lipase-catalyzed acylation reactions as the key steps. The versatility of the intermediates was demonstrated by converting them to the titled tetrahydropyran, macrolide, and macrodiolide compounds using standard synthetic protocols.