diethylsulfamoyl-guanidine | 5615-97-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: diethylsulfamoyl-guanidine
• 英文别名: N,N-Diaethyl-N'-carbamimidoyl-sulfamid；Diaethylsulfamoyl-guanidin；Guanidinsulfonsaeure-diaethylamid；Diaethylamidosulfonyl-guanidin；2-(Diethylsulfamoyl)guanidine
• CAS: 5615-97-4
• 化学式: C₅H₁₄N₄O₂S
• 分子量: 194.258
• InChiKey: JEKYTIIJCLZCFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethylsulfamoyl-guanidine 、 苯甲酸酐 在 碳酸甲丙酯 作用下， 生成 N-benzoyl-N'-diethylsulfamoyl-guanidine
  参考文献：
  名称：

  Cortisol secretion throughout the day, perceptions of the work environment, and negative affect

  摘要：

  The effects of explanatory variables derived from a work stress model (the effort-reward imbalance model) on salivary cortisol were assessed A multilevel analysis was used to distinguish the effects of single occasion and multiple occasion measurements of work stress and effect an cortisol. The single (or cross-sectional) factors include Effort-Reward imbalance (ERI), need for control negative affect, and other enduring factors (type of occupation, gender and smoking). The multiple occasion measurements include momentary negative mood, Momentary Demand-Satisfaction Ratio (MD-SR), sleep quality, work load (workday versus day off) at work (versus not being at the workplace). and lunch. The effect of time of day on cortisol was controlled for before the effects of these variables were determined.Momentary negative mood but not trait negative affect was positively associated with ambulatory measured cortisol. The variables from the work stress model-effort, reward need for control, and the multiple occasion measurements of demand arm satisfaction-did not affect cortisol. As could be expected, time of day had an effect on cortisol ,but a hypothesised interaction with momentary negative mood was not found. Additionally, the results show that the time course of cortisol differs between individuals and that the effect of sleep quality on cortisol can vary from person to person. This points to the necessity of continued efforts to single out sources of individual variability.The finding that variables derived from the effort-reward imbalance model are not related with cortisol does not support the hypothesis that ERI lends to short-term changes in cortisol, indicating no relation with hypothalamic-pituitary-adrenal (HPA) axis activity. On the other hand the present results invite further qualification of negative affect as a potential determinant of HPA activity at least, as far as can be deduced from cortisol measurements.

  DOI：

  10.1007/bf02895668
• 作为产物：
  描述：

  二乙基磺酰氯 、 胍 在 乙醇 作用下， 生成 diethylsulfamoyl-guanidine
  参考文献：
  名称：

  Perrot, Bulletin de la Societe Chimique de France, 1946, p. 554,557

  摘要：

  DOI：

文献信息

• Perrot, Bulletin de la Societe Chimique de France, 1946, p. 554,557
  作者：Perrot

  DOI：——

  日期：——
• Cortisol secretion throughout the day, perceptions of the work environment, and negative affect
  作者：Eamonn K. S. Hanson、Cora J. M. Maas、Theo F. Meijman、Guido L. R. Godaert

  DOI：10.1007/bf02895668

  日期：2000.12

  The effects of explanatory variables derived from a work stress model (the effort-reward imbalance model) on salivary cortisol were assessed A multilevel analysis was used to distinguish the effects of single occasion and multiple occasion measurements of work stress and effect an cortisol. The single (or cross-sectional) factors include Effort-Reward imbalance (ERI), need for control negative affect, and other enduring factors (type of occupation, gender and smoking). The multiple occasion measurements include momentary negative mood, Momentary Demand-Satisfaction Ratio (MD-SR), sleep quality, work load (workday versus day off) at work (versus not being at the workplace). and lunch. The effect of time of day on cortisol was controlled for before the effects of these variables were determined.Momentary negative mood but not trait negative affect was positively associated with ambulatory measured cortisol. The variables from the work stress model-effort, reward need for control, and the multiple occasion measurements of demand arm satisfaction-did not affect cortisol. As could be expected, time of day had an effect on cortisol ,but a hypothesised interaction with momentary negative mood was not found. Additionally, the results show that the time course of cortisol differs between individuals and that the effect of sleep quality on cortisol can vary from person to person. This points to the necessity of continued efforts to single out sources of individual variability.The finding that variables derived from the effort-reward imbalance model are not related with cortisol does not support the hypothesis that ERI lends to short-term changes in cortisol, indicating no relation with hypothalamic-pituitary-adrenal (HPA) axis activity. On the other hand the present results invite further qualification of negative affect as a potential determinant of HPA activity at least, as far as can be deduced from cortisol measurements.