1-[(3,4-dimethoxyphenyl)(piperidin-1-yl)methyl]naphthalen-2-ol | 1384975-40-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-[(3,4-dimethoxyphenyl)(piperidin-1-yl)methyl]naphthalen-2-ol
• 英文别名: 1-[(3,4-Dimethoxyphenyl)-piperidin-1-ylmethyl]naphthalen-2-ol
• CAS: 1384975-40-9
• 化学式: C₂₄H₂₇NO₃
• 分子量: 377.483
• InChiKey: DQJXCPBZHOMAFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  哌啶 、 3,4-二甲氧基苯甲醛 、 2-萘酚 以 二氯甲烷 为溶剂， 反应 2.0h， 以84%的产率得到1-[(3,4-dimethoxyphenyl)(piperidin-1-yl)methyl]naphthalen-2-ol
  参考文献：
  名称：

  Catalyst-Free, One-Pot, Expeditious Synthesis of Aminoalkylnaphthols at Room Temperature

  摘要：

  Aminoalkylnaphthols possess several biological and catalytic activities. A methodology has been developed for the multicomponent one-pot synthesis of aminoalkylnaphthols in dichloromethane under catalyst-free conditions at room temperature. The present approach possesses several advantages such as excellent yields, quick reaction time, mild reaction conditions, and very easy purification processes. Thirteen new compounds in addition to six known compounds have been synthesized by this methodology.

  DOI：

  10.1080/00397911.2011.575524