2-(3-iodo-7,9-dimethyl-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde | 1413432-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(3-iodo-7,9-dimethyl-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde
• CAS: 1413432-41-3
• 化学式: C₂₀H₁₈INO₃
• 分子量: 447.272
• InChiKey: URYOAOSOWIPWRI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-(3-iodo-7,9-dimethyl-2,8-dioxo-4-(o-tolyl)-1-azaspiro[4.5]deca-3,6,9-trien-1-yl)acetaldehyde 在 5a(R),10b(S)-5a,10b-dihydro-2-(pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium tetrafluoroborate 、 双(三甲基硅烷基)氨基钾 作用下， 以 甲苯 为溶剂， 反应 40.0h， 以98%的产率得到
  参考文献：
  名称：

  Diastereoselective and Enantioselective Desymmetrization of α-Substituted Cyclohexadienones via Intramolecular Stetter Reaction

  摘要：

  Highly diastereoselective and enantioselective desymmetrization of alpha-substituted cyclohexadienones via NHC-catalyzed intramolecular Stetter reaction was realized. Amino-indanol derived triazolium salt bearing a C6F5 group was found to be the optimal catalyst precursor in the intramolecular Stetter reaction furnishing tricyclic products bearing multi-stereocenters in up to 96% yield and >99% ee.

  DOI：

  10.1021/jo3022555