Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester | 208391-09-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester
• CAS: 208391-09-7
• 化学式: C₄₄H₅₅N₇O₁₀Si
• 分子量: 870.047
• InChiKey: ZIHGVGWQVJUZKH-NFXQKKKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.81
• 重原子数：
  62.0
• 可旋转键数：
  12.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  188.81
• 氢给体数：
  2.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  2-氰乙基N,N-二异丙基氯亚磷酰胺 、 Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester 在 N-甲基咪唑 、 2,4,6-三甲基吡啶 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Oligoribonucleotides containing 8-oxo-7,8-dihydro-guanosine and 8-oxo-7,8-dihydro-2′-O-methylguanosine: Synthesis and base pairing properties

  摘要：

  7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2'-O-methylguanosine(8-oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8-oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis was characterized. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00150-4
• 作为产物：
  描述：

  8-oxo-7,8-dihydro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-N²-acetylguanine 在 吡啶 、 potassium tert-butylate 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 甲醇 为溶剂， 反应 11.5h， 生成 Dimethyl-carbamic acid 2-acetylamino-9-{(2R,3R,4R,5R)-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7-dimethylcarbamoyl-8-oxo-8,9-dihydro-7H-purin-6-yl ester
  参考文献：
  名称：

  Oligoribonucleotides containing 8-oxo-7,8-dihydro-guanosine and 8-oxo-7,8-dihydro-2′-O-methylguanosine: Synthesis and base pairing properties

  摘要：

  7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2'-O-methylguanosine(8-oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8-oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis was characterized. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00150-4