4.5-Triazolo-2.3;6.7-dibenzo-cycloheptatrienon | 98089-72-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4.5-Triazolo-2.3;6.7-dibenzo-cycloheptatrienon
• 英文别名: 3,4,5-Triazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2,5,7,9,11,14,16-octaen-13-one
• CAS: 98089-72-6
• 化学式: C₁₅H₉N₃O
• 分子量: 247.256
• InChiKey: BUKZFVKULBJNEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof
  申请人：——

  公开号：US20040142870A1

  公开（公告）日：2004-07-22

  The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. The present invention also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.

  本发明提供了一种化学修饰的人类生长激素（hGH），其制备方法是在蛋白质的 N 端苯丙氨酸上附着聚乙二醇丁醛分子。根据本发明化学修饰的蛋白质可能比未修饰的 hGH 具有更持久的 hGH 活性，从而可以减少剂量和安排用药时间。本发明还包括用于治疗和/或预防使用生长激素有益的疾病或紊乱的方法。
• TREATMENT OF RETT SYNDROME AND OTHER DISORDERS
  申请人：Sur Mriganka

  公开号：US20090099077A1

  公开（公告）日：2009-04-16

  The invention relates to methods for treatment of Rett Syndrome and other disorders of synaptic function and maturation using IGF1, (1-3)IGF-1, (1-3)IGF-1 analog(s) and/or related therapeutic molecules.
• US7994127B2
  申请人：——

  公开号：US7994127B2

  公开（公告）日：2011-08-09
• [EN] 2-SUBSTITUTED DIBENZO[A,E]1,2,3-TRIAZOLO[4,5-C][7]ANNULEN-8-ONES AS GROWTH HORMONE SECRETAGOGUES<br/>[FR] DIBENZO[A,E]1,2,3-TRIAZOLO[4,5-C][7]ANNULENE-8-ONES A SUBSTITUTION EN 2, COMME SECRETAGOGUES DE L'HORMONE DE CORSANTE
  申请人：——

  公开号：WO2002056873A3

  公开（公告）日：2003-08-07

  [EN] The invention relates to methods of treating or preventing diseases or conditions caused by deficiencies in growth hormone by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones. Such diseases or conditions include osteoporosis, osteopenia and obesity. Furthermore, the invention relates to methods of stimulating the release of growth hormone in a mammal by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones. Finally, the invention further relates to promoting bone growth in a mammal, particularly endocortical, periosteal, or cancellous bone growth, by administration of 2-substituted dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulen-8-ones.
  [FR] L'invention concerne des procédés relatifs au traitement ou à la prévention d'affections ou de maladies liées aux carences en hormone de croissance, consistant à administrer des dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulène-8-ones à substitution en 2. Parmi les maladies ou affections visées, on peut citer les cas suivants: ostéoporose, ostéopénie et obésité. L'invention concerne également des procédés relatifs à la stimulation de la sécrétion de l'hormone de croissance chez un mammifère, par administration de dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulène-8-ones à substitution en 2. Enfin, l'invention concerne la stimulation de la croissance osseuse chez un mammifère, en particulier la croissance osseuse du type endocortical, périostique ou spongieux, par administration de dibenzo[a,e]1,2,3-triazolo[4,5-c][7]annulène-8-ones à substitution en 2.