2',5,7-trihydroxyneoflavone | 114590-62-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 2',5,7-trihydroxyneoflavone
• 英文别名: 5,7-Dihydroxy-4-(2-hydroxyphenyl)-2H-1-benzopyran-2-one；5,7-dihydroxy-4-(2-hydroxyphenyl)chromen-2-one
• CAS: 114590-62-4
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.241
• InChiKey: STTFUJUCFPJSOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2-异丙氧基苯基)乙酮 在 盐酸 、 三氯化硼 、 sodium hydride 作用下， 以 乙醇 为溶剂， 反应 79.0h， 生成 2',5,7-trihydroxyneoflavone
  参考文献：
  名称：

  Iinuma, Munekazu; Tanaka, Toshiyuki; Hamada, Koji, Chemical and pharmaceutical bulletin, 1987, vol. 35, # 9, p. 3909 - 3913

  摘要：

  DOI：

文献信息

• Apparatus and methods for drug delivery using multiple reservoirs
  申请人：Clearside Biomedical, Inc.

  公开号：US10188550B2

  公开（公告）日：2019-01-29

  A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.

  一个滤芯，包括一个限定内容积的第一部件和一个放置在其中的第二部件，被放置在一个外壳中。第一储液器位于第二部件远端位置的内腔中。第一构件部分设置在由外壳限定的第二储液器中。第二构件被配置为可从第一位置向第二位置移动，在第一位置，第一贮液器含有药物，第二贮液器与内腔流体隔离，在第二位置，第一贮液器和第二贮液器与内腔流体相通，从而第二贮液器从第一贮液器接收一定量的药物。第一构件和第二构件共同相对于第二贮液器移动，以将药物从第二贮液器中排出。
• Ocular injection kit, packaging, and methods of use
  申请人：Clearside Biomedical, Inc.

  公开号：US10390901B2

  公开（公告）日：2019-08-27

  An apparatus includes a first tray member, a second tray member, and a lid. The first tray member has a first portion and a second portion. The first portion defines a first volume, and the second portion defines a second volume configured to receive a medicament container. The second tray member defines a third volume having a sidewall including a retention portion configured to retain an ocular injector within the third volume. The second tray member is coupled within first volume such that the sidewall of the second tray member and a sidewall of the first tray member enclose the ocular injector. The lid is coupled to the first tray member about the first volume, and is constructed from a material formulated to maintain sterility of the first volume.

  一种设备包括一个第一托盘部件、一个第二托盘部件和一个盖子。第一托盘部件有一个第一部分和一个第二部分。第一部分限定了一个第一容积，第二部分限定了一个第二容积，该第二容积用于接收药剂容器。第二托盘构件限定了一个第三容积，该容积具有一个侧壁，该侧壁包括一个用于将眼科注射器保留在第三容积内的保留部分。第二托盘部件连接在第一容积内，使第二托盘部件的侧壁和第一托盘部件的侧壁包围眼用注射器。盖子围绕第一容积与第一托盘构件相连，由可保持第一容积无菌的材料制成。
• Apparatus and methods for ocular injection
  申请人：CLEARSIDE BIOMEDICAL, INC.

  公开号：US10517756B2

  公开（公告）日：2019-12-31

  An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

  一种设备包括一个与药剂容器相连的外壳，药剂容器与针头相连。注射组件安装在外壳内，包括储能部件和驱动杆。致动杆的远端部分位于药剂容器内。储能部件可对驱动杆的近端部分产生足够的力，使驱动杆的远端部分在药剂容器内移动。这样，当针头的远端位于目标位置的第一区域内时，就可以通过针头从药剂容器中输送至少一部分物质。当针头的远端位于目标位置的第二区域内时，力不足以在药剂容器内移动致动杆的远端部分。
• Devices and methods for adjusting the insertion depth of a needle for medicament delivery
  申请人：Clearside Biomedical, Inc.

  公开号：US10973681B2

  公开（公告）日：2021-04-13

  An apparatus includes a housing, an adjustment member, and a microneedle. The housing can be coupled to a medicament container, and includes a hub surface that can contact a target surface. The adjustment member is within the housing and separates an inner volume of the housing into a first chamber and a second chamber. The first chamber is fluidically coupled with the medicament container. The adjustment member, which is coupled to the microneedle, can transition between a first configuration and a second configuration. A proximal end portion of the microneedle is fluidically coupled to the first chamber such that a substance can be conveyed from the medicament container through the microneedle. A distal tip of the microneedle extends from the hub surface by a first distance when the adjustment member is in the first configuration, and by a second distance when the adjustment member is in the second configuration.

  一种仪器包括一个外壳、一个调节部件和一个微针。外壳可与药物容器连接，并包括一个可接触目标表面的轮毂表面。调节部件位于外壳内，并将外壳的内部容积分隔成第一腔室和第二腔室。第一腔室与药剂容器流体连接。调节部件与微针相连，可在第一构型和第二构型之间转换。微针的近端部分与第一腔室流体连接，这样就可以通过微针从药剂容器中输送物质。当调节部件处于第一构型时，微针的远端从轮毂表面延伸出第一距离，当调节部件处于第二构型时，微针的远端从轮毂表面延伸出第二距离。
• Method for determining the therapeutic activity of metalloproteinase inhibitor compounds, new inhibitor compounds, and the therapeutic use thereof
  申请人：POLIFARMA S.p.A.

  公开号：EP0758021B1

  公开（公告）日：2006-03-29