(E)-5-(6-Methoxy-2,8-dimethyl-2H-chromen-2-yl)-2-methyl-pent-2-enal | 139367-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (E)-5-(6-Methoxy-2,8-dimethyl-2H-chromen-2-yl)-2-methyl-pent-2-enal
• 英文别名: (E)-5-(6-methoxy-2,8-dimethylchromen-2-yl)-2-methylpent-2-enal
• CAS: 139367-75-2
• 化学式: C₁₈H₂₂O₃
• 分子量: 286.371
• InChiKey: GFYQESKZMOLXKQ-AWNIVKPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  dihydroxysargaquinone 在 吡啶 、 chromium trioxide-pyridine complex 作用下， 反应 48.0h， 生成 (E)-5-(6-Methoxy-2,8-dimethyl-2H-chromen-2-yl)-2-methyl-pent-2-enal
  参考文献：
  名称：

  Cytotoxic Activity of Marine Algae and a Cytotoxic Principle of the Brown Alga Sargassum tortile.

  摘要：

  Partition fractions of hexane, CCl4 and CHCl3 from methanolic extracts of marine algae were each examined for cytotoxic activities against cultured P-388 lymphocytic leukemia cells. Cytotoxic activities were found for partition fractions of 21 species of seaweed. Bioactivity-guided fractionation of the CCl4 partition fraction from Sargassum tortile, exhibiting the most prominent activity, afforded dihydroxysargaquinone (1) and sargatriol (2) previously isolated from this alga. The former was evaluated as a cytotoxic principle, and the latter, showing mederate activity, was suggested to be an artifact derived from 1 during the isolation procedure.

  DOI：

  10.1248/cpb.39.2129