4-[2-(3,5-Dihydroxy-phenyl)-vinyl]-benzoic acid methyl ester | 585521-17-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-[2-(3,5-Dihydroxy-phenyl)-vinyl]-benzoic acid methyl ester
• 英文别名: 3,5-dihydroxy-4'-carbomethoxy-trans-stilbene；methyl 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzoate
• CAS: 585521-17-1
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: HKZACLXORGUZHU-NSCUHMNNSA-N

物化性质

• 沸点：
  473.6±24.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[2-(3,5-Dihydroxy-phenyl)-vinyl]-benzoic acid methyl ester 在 偶氮二甲酸二异丙酯 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Liquid Crystalline Octopus: An Alternative Class of Mesomorphic Dendrimers

  摘要：

  The synthesis and the mesomorphic properties of a new series of liquid crystalline dendrimers, referred thereafter as to octopus dendrimers owing to their eight sidearms, are reported. In these dendritic systems, the arborescence is constituted of mesogenic segments and aliphatic spacers, and as such they differ quite substantially from the classical end-functionalized dendrimers whose dentritic core is more flexible. Such a molecular design was adopted in order for the internal mesogenic segments-constituting the skeleton of the dendrimer-to participate at every level of the molecular organization within the mesophases. The dendritic branches, prepared by a mixed convergent/divergent method, were attached to a tetrapodant central core to yield second generation dendrimers via amido linkage. X-ray diffraction studies showed that the acidic dendron precursors and the final dendrimers exhibit a hexagonal columnar mesophase, whose mesophase stability was found to depend on the number and position of the terminal alkoxy chains. The high density of aliphatic chains imposes curved interfaces at all hierarchical levels of the dendrimers, i.e., between the pro-mesogenic units, the aliphatic spacers, and the terminal chains, forcing the molecules to adopt a wedgelike conformation, promoting the self-assembling toward a supramolecular columnar organization. Because of their original molecular structure, the internal columnar "hard" core of the columns is compatible with an onion-type structure, i.e., made up of successive, concentric crowns occupied by aromatic and aliphatic constituents, as deduced from the analysis of the X-ray diffraction data.

  DOI：

  10.1021/ma034038i
• 作为产物：
  描述：

  4-[(E)-2-(3,5-Dimethoxy-phenyl)-vinyl]-benzoic acid ethyl ester 在 硫酸 、 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 4-[2-(3,5-Dihydroxy-phenyl)-vinyl]-benzoic acid methyl ester
  参考文献：
  名称：

  液晶章鱼树枝状聚合物：具有异常中间相形态的块状分子

  摘要：

  报道了几种新的主链液晶树枝状聚合物的合成和介晶性质，此后根据它们的八个侧臂将其命名为章鱼树枝状聚合物。在这些树突系统中，树状结构由各向异性片段确保，充当具有双重多重性的分支细胞，它们结合在树突结构的每个节点上。以这种方式，这些化合物与经典的末端官能化液晶树枝状聚合物（最常报道的系统）完全不同。根据我们之前关于纯同质系统的报告，即构成树枝状矩阵的构建块都是相同的，已经制备了几种由不同各向异性块组成的异质系统。使用模块化结构合成树枝状分支和相应的树枝状聚合物。偏振光学显微镜和 X 射线衍射研究表明，所有这些新的章鱼树枝状聚合物都表现出具有新形态的近晶相或柱状相，中间相的性质取决于连接到外围基团的末端链的数量。这些异形树枝状聚合物的介晶现象是根据它们的内在结构进行讨论的，并与类似的同形章鱼系统进行比较。近晶相和柱状相内的分子组织模型是在小布拉格角 X 射线衍射研究的基础上提出的，并得到分子模型的支持。而且，

  DOI：

  10.1021/ja031506v

文献信息

• Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods
  申请人：——

  公开号：US20030073712A1

  公开（公告）日：2003-04-17

  Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.

  细胞保护化合物，其中许多是酚类衍生物，其特点是具有特定共轭键的取代酚，对于治疗某些缺血或炎症性疾病非常有用，包括但不限于中风、心肌梗死、充血性心力衰竭以及以炎症或氧化损伤为特征的皮肤疾病。它们还可用于制造用于治疗这些疾病的药物和化妆品配方。
• Sirtuin modulators as inhibitors of cytomegalovirus
  申请人：The Trustees of Princeton University

  公开号：US10813934B2

  公开（公告）日：2020-10-27

  Agents and methods of inhibiting or improving the growth of viruses are provided.

  提供了抑制或改善病毒生长的制剂和方法。
• Compositions and methods for selectively activating human sirtuins
  申请人：Howitz T. Konrad

  公开号：US20060014705A1

  公开（公告）日：2006-01-19

  Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.

  提供了鉴定 SIRT5 和/或 SIRT1 选择性激活剂的方法以及使用这些选择性激活剂调节 SIRT5 和/或 SIRT1 的方法。
• CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS, AND METHODS
  申请人：Galileo Pharmaceuticals, Inc.

  公开号：EP1435894A2

  公开（公告）日：2004-07-14
• EP1435894A4
  申请人：——

  公开号：EP1435894A4

  公开（公告）日：2005-07-06