2-tert.-Butyl-2,3-dihydro-1H-benzisochinolin | 46789-46-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-tert.-Butyl-2,3-dihydro-1H-benzisochinolin
• 英文别名: 2-tert-butyl-2,3-dihydro-1H-benzo[de]isoquinoline；2-Tert-butyl-1,3-dihydrobenzo[de]isoquinoline
• CAS: 46789-46-2
• 化学式: C₁₆H₁₉N
• 分子量: 225.334
• InChiKey: OQPRDNXXKOCRBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• 6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
  申请人：Mueller Stephan-Georg

  公开号：US20120165304A1

  公开（公告）日：2012-06-28

  The present invention relates to compounds defined by formula (I), wherein the groups X, Y, W and R 1 to R 4 are defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are agonists of the 5-HT2C receptor, and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this receptor, such as metabolic and CNS-related disorders.

  本发明涉及由式(I)定义的化合物，其中X、Y、W和R1至R4基团如权利要求1中所定义，具有有价值的药理活性。特别地，这些化合物是5-HT2C受体激动剂，因此适用于治疗和预防可以受到该受体抑制影响的疾病，例如代谢和中枢神经系统相关疾病。
• INHIBITORS OF KRAS G12C
  申请人：BEIGENE, LTD.

  公开号：US20220389021A1

  公开（公告）日：2022-12-08

  Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.
• US9346816B2
  申请人：——

  公开号：US9346816B2

  公开（公告）日：2016-05-24