1-(2-methylbenzofuran-3-yl)-2-phenyl-ethanone | 18703-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 1-(2-methylbenzofuran-3-yl)-2-phenyl-ethanone
• 英文别名: 1-(2-Methyl-1-benzofuran-3-yl)-2-phenylethanone；1-(2-methyl-1-benzofuran-3-yl)-2-phenylethanone
• CAS: 18703-76-9
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: PNKFIKKTYFVPHE-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-(2-methylbenzofuran-3-yl)-2-phenyl-ethanone 在 一水合肼 作用下， 以 乙醇 为溶剂， 以18.1 %的产率得到2-(5-benzyl-3-methyl-1H-pyrazol-4-yl)phenol
  参考文献：
  名称：

  [EN] ABAD INHIBITOR COMPOUNDS
  [FR] COMPOSÉS INHIBITEURS D'ABAD

  摘要：

  The present invention concerns Amyloid Binding Alcohol Dehydrogenase (ABAD) inhibitors (I) or (II) that interact non- competitively with nicotinamide adenine dinucleotide + H (NADH). Inhibition of ABAD is useful in the treatment or prophylaxis of disease, including Alzheimer's disease (AD) and cancer. Accordingly, the present invention also concerns ABAD inhibitors for use as a medicament, specifically for use in the treatment of Alzheimer's disease and/or cancer.

  公开号：

  WO2023026060A1