2-(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-N-[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]sulfonylacetamide | 1307892-86-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-N-[4-[(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenyl]sulfonylacetamide
• CAS: 1307892-86-9
• 化学式: C₄₃H₄₅N₃O₇S
• 分子量: 747.912
• InChiKey: KFSJRUGGVUFTTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  54
• 可旋转键数：
  12
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME
  申请人：Manetsch Roman

  公开号：US20130203709A1

  公开（公告）日：2013-08-08

  The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
• [EN] ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME<br/>[FR] ACYLSULFONAMIDES ET PROCÉDÉS POUR PRODUIRE CEUX-CI
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2012021486A2

  公开（公告）日：2012-02-16

  The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.