(4R,6S)-4-Aminomethyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-piperidin-2-one | 444615-90-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (4R,6S)-4-Aminomethyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-piperidin-2-one
• CAS: 444615-90-1
• 化学式: C₂₃H₃₂N₂O₂Si
• 分子量: 396.605
• InChiKey: DKDRMJQEAOIXOZ-MOPGFXCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  28.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  64.35
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (4R,6S)-4-Aminomethyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-piperidin-2-one 在 四丁基氟化铵 作用下， 生成
  参考文献：
  名称：

  Stereocontrolled synthesis of enantiopure diversely functionalized prototypical piperidinone libraries, and constrained analogs of 4-substituted 2-amino adipic acid

  摘要：

  Enantiopure 2-substituted 4.5-unsaturated piperidinones were subjected to stereocontrolled nitroalkane additions and the corresponding products were further manipulated to produce 4-aminomethyl derivatives. Diverse substitution led to a set of 4-arylsulfonamides and O-carbamates as examples of prototypical piperidinone libraries with two sites of diversity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00183-1
• 作为产物：
  描述：

  (S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-6-oxopiperidine-1-carboxylate 在 palladium on activated charcoal 苯基溴化硒 、 氢气 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三氟乙酸 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 (4R,6S)-4-Aminomethyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-piperidin-2-one
  参考文献：
  名称：

  Stereocontrolled synthesis of enantiopure diversely functionalized prototypical piperidinone libraries, and constrained analogs of 4-substituted 2-amino adipic acid

  摘要：

  Enantiopure 2-substituted 4.5-unsaturated piperidinones were subjected to stereocontrolled nitroalkane additions and the corresponding products were further manipulated to produce 4-aminomethyl derivatives. Diverse substitution led to a set of 4-arylsulfonamides and O-carbamates as examples of prototypical piperidinone libraries with two sites of diversity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00183-1