5-Hydroxy-2,2,8-trimethylpyrano[3,2-b]xanthen-6-one | 1244759-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-Hydroxy-2,2,8-trimethylpyrano[3,2-b]xanthen-6-one
• CAS: 1244759-95-2
• 化学式: C₁₉H₁₆O₄
• 分子量: 308.334
• InChiKey: BEJIOVSRCLAPJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,4-二甲氧基-2-甲基-2-丁醇 、 1,3-dihydroxy-7-methyl-9H-xanthen-9-one 在 吡啶 作用下， 反应 4.0h， 以42.6%的产率得到6-Hydroxy-3,3,9-trimethylpyrano[2,3-c]xanthen-7-one
  参考文献：
  名称：

  Anti-AIDS agents 83. Efficient microwave-assisted one-pot preparation of angular 2,2-dimethyl-2H-chromone containing compounds

  摘要：

  A novel and efficient microwave-assisted one-pot reaction was developed to synthesize angular 2,2-dimethyl-2H-chromone-containing compounds, which is the first and key step in the synthesis of potent DCK and DCP anti-HIV agents The newly developed microwave synthesis conditions dramatically shortened the reaction time from 2 clays to 4 h with improved yields (c) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2010.06.058

文献信息

• Anti-AIDS agents 83. Efficient microwave-assisted one-pot preparation of angular 2,2-dimethyl-2H-chromone containing compounds
  作者：Ting Zhou、Qian Shi、Kuo Hsing Lee

  DOI：10.1016/j.tetlet.2010.06.058

  日期：2010.8

  A novel and efficient microwave-assisted one-pot reaction was developed to synthesize angular 2,2-dimethyl-2H-chromone-containing compounds, which is the first and key step in the synthesis of potent DCK and DCP anti-HIV agents The newly developed microwave synthesis conditions dramatically shortened the reaction time from 2 clays to 4 h with improved yields (c) 2010 Elsevier Ltd All rights reserved