2-(Piperazin-1-ylamino)ethanol | 1314977-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(Piperazin-1-ylamino)ethanol
• CAS: 1314977-19-9
• 化学式: C₆H₁₅N₃O
• mdl: MFCD19227609
• 分子量: 145.205
• InChiKey: IIYOBOCCLUKUNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-[4-(2-chloroethoxy)phenyl]-4-[(4-methyl-1H-indol-5-yl)amino]nicotinonitrile 、 2-(Piperazin-1-ylamino)ethanol 在 sodium iodide 作用下， 以 乙二醇二甲醚 为溶剂， 生成
  参考文献：
  名称：

  Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors

  摘要：

  The key intermediate, 4-chloro-5-iodo-3-pyridinecarbonitrile, allowed for ready optimization of the PKC theta inhibitory activity of a series of 3-pyridinecarbonitriles. Analog 13b with a 4-methylindol-5-ylamino group at C-4 and a 4-(2-(4-methylpiperazin-1-yl)ethoxy) phenyl group at C-5 had an IC(50) value of 7.4 nM for the inhibition of PKC theta. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.126

文献信息

• Nucleic acid comprising zwitterionic nucleotides
  申请人：novosom AG

  公开号：EP2143726A1

  公开（公告）日：2010-01-13

  This invention provides pH-responsive zwitterionic nucleotides and nucleic acids comprising said nucleotides, wherein said zwitterions are constituted from one or more anionic internucleoside linkages and one or more cationic moieties and said zwitterionic nucleotides further comprise either one or more hydrophobic moieties or one or more TEE's with the general structure (I) Hydrophobic element - pH-responsive hydrophilic elements (I).

  本发明提供了 pH 响应型齐聚物核苷酸和包含所述核苷酸的核酸，其中所述齐聚物由一个或多个阴离子核苷内连接和一个或多个阳离子分子构成，所述齐聚物核苷酸进一步包含一个或多个疏水分子或一个或多个 TEE，其一般结构为 (I) 疏水元件--pH 响应亲水元件 (I)。
• NUCLEIC ACID COMPRISING ZWITTERIONIC NUCLEOTIDES
  申请人：Panzner Steffen

  公开号：US20110137019A1

  公开（公告）日：2011-06-09

  This invention provides pH-responsive zwitterionic nucleotides and nucleic acids comprising said nucleotides, wherein said zwitterions are constituted from one or more anionic internucleoside linkages and one or more cationic moieties and said zwitterionic nucleotides further comprise either one or more hydrophobic moieties or one or more TEE's with the general structure (I) Hydrophobic element-pH-responsive hydrophilic elements (I).
• CONSTRUCTION OF CELL PENETRATING NUCLEIC ACIDS
  申请人：Panzner Steffen

  公开号：US20150112051A1

  公开（公告）日：2015-04-23

  This invention provides pH-responsive zwitterionic nucleotides and nucleic acids comprising said nucleotides, wherein said zwitterions are constituted from one or more anionic internucleoside linkages and one or more cationic moieties and said zwitterionic nucleotides further comprise either one or more hydrophobic moieties or one or more TEE's with the general structure (I) Hydrophobic element-pH-responsive hydrophilic elements (I).
• US8957191B2
  申请人：——

  公开号：US8957191B2

  公开（公告）日：2015-02-17