cis-[Rh2(μ-acetato)2(dipyrido[3,2-a:2',3'-c]phenazine)(2,2'-bipyridine)](2+) | 868382-41-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: cis-[Rh2(μ-acetato)2(dipyrido[3,2-a:2',3'-c]phenazine)(2,2'-bipyridine)](2+)
• CAS: 868382-41-6
• 化学式: C₃₂H₂₄N₆O₄Rh₂
• 分子量: 762.391
• InChiKey: BPRYVLZPYIYPCP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二吡啶并[3,2-a:2',3'-c]吩嗪 、 cis-[Rh2(μ-acetato)2(2,2'-bipyridine)(η1-acetato)(methanol)](acetate) 以 乙腈 为溶剂， 生成 cis-[Rh2(μ-acetato)2(dipyrido[3,2-a:2',3'-c]phenazine)(2,2'-bipyridine)](2+)
  参考文献：
  名称：

  Photocytotoxicity of a New Rh₂(II,II) Complex:  Increase in Cytotoxicity upon Irradiation Similar to That of PDT Agent Hematoporphyrin

  摘要：

  A new type of heteroleptic dirhodium complex cis-[Rh-2(mu-O2CCH3)(2)-(bpy)(dppz)](2+) (3) was synthesized and its potential as a photodynamic therapy (PDT) agent was investigated. Although 27% hypochromicity of the absorption of 3 in the near-UV and visible regions is observed in the presence of duplex DNA, relative viscosity measurements reveal that the complex does not intercalate between the DNA bases. The DNA photocleavage with visible light by 3 proceeds via both oxygen dependent and independent mechanisms, and it is more efficient than that of related complexes. The increase in the cytotoxicity of 3 towards human skin cells is similar to that of hematoporphyrin, a key ingredient in a PDT drug currently in use. This feature makes this complex a useful candidate for further PDT studies.

  DOI：

  10.1021/ic0500715