17a-乙炔基雌甾-5(10)-烯-3b,17b-二醇 | 2307-97-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 17a-乙炔基雌甾-5(10)-烯-3b,17b-二醇
• 英文名称: 17α-Ethinyl-5(10)-estren-3β,17β-diol
• 英文别名: 3-beta-Hydroxynorethynodrel；(3S,8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
• CAS: 2307-97-3
• 化学式: C₂₀H₂₈O₂
• 分子量: 300.441
• InChiKey: XSQAQKNJHGGMRV-CHZZJNJQSA-N

物化性质

• 熔点：
  132°C
• 沸点：
  381.66°C (rough estimate)
• 密度：
  1.0597 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异炔诺酮 生成 17a-乙炔基雌甾-5(10)-烯-3b,17b-二醇
  参考文献：
  名称：

  3-keto-19-nor-5（10）-ene类固醇的微生物还原为相应的3-羟基结构

  摘要：

  17β-羟基-19-正-雄酮-（5（10））-开（3）在微生物学上变成3α.17β-和3β的混合物。17β-二羟基-19-正雄酮-（5（10））减少。用特殊的酵母可以还原3β-羟基结构。用相同的菌株产生了与其他相应的3-酮基不同的3β-羟基-5（10）-烯结构。

  DOI：

  10.1002/cber.19701030232

文献信息

• The preparation of 3α- and 3β, 17β-dihydroxy-17α-ethynyl-estr-5(10)-ene 1
  作者：K.H. Palmer、C.E. Cook、F.T. Ross、J. Dolar、M.E. Twine、M.E. Wall

  DOI：10.1016/0039-128x(69)90093-2

  日期：1969.7

  with lithium tri(t-butoxy) hydride yielded predominantly (98%) the equatorial Sec-alcohol II together with 27. of the axial 3β-alcohol III. Reduction of norethynodrel with sodium borohydride resulted in increased yields of the 3β alcohol III, the ratio of the 3α to 3β-alcohols varying from 4:1 to 3:1 depending upon the solvent used. The 3β-aicohol III was obtained in 38% yield following reduction of

  摘要 Norethynodrel (1, 17β-hydroxy-17α-ethynyl-estr-4-en-3-one) 在 -70°C 下用三（叔丁氧基）氢化锂还原时主要 (98%) 产生赤道 Sec-醇II 与 27. 的轴向 3β-醇 III。用硼氢化钠还原炔诺酮导致 3β 醇 III 的产率增加，3α 与 3β-醇的比例从 4:1 到 3:1 不等，这取决于所用的溶剂。用氢化二异丁基铝还原酮 I 后，以 38% 的产率获得 3β-醇 III。最有效的 3β-醇 III 合成是通过 MeerweinPondorff 还原酮 I 在非常短的反应时间内进行 (9)。在另一种途径中，赤道 3α-醇 II 通过 3α-均三甲苯磺酰氧基衍生物 IVd 和 3β 甲酸酯 V 转化为 3β-轴醇 III。
• Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
  申请人：West D. Michael

  公开号：US20080070303A1

  公开（公告）日：2008-03-20

  This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
• Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods
  申请人：Federoff Howard J.

  公开号：US20080226601A1

  公开（公告）日：2008-09-18

  Disclosed are compositions and methods for reducing the severity of a birth defect in a mammal by exposing the mammal (e.g., in utero) to a herpes virus amplicon particle comprising a cis element-flanked transgene and a sequence encoding a transposase. Upon expression, the transposase inserts the transgene into the genome of a cell (e.g., a neuron) within the mammal and the transgene expresses a polypeptide or RNA that compensates for a protein or gene defect that is causally associated with the birth defect.
• METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY
  申请人：West Michael D.

  公开号：US20100184033A1

  公开（公告）日：2010-07-22

  Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated 20 or more population doublings. This invention also provides novel compositions of such subpopulations of cells and methods to propagate and differentiate said cells.
• US4018919A
  申请人：——

  公开号：US4018919A

  公开（公告）日：1977-04-19