(+/-)-2-Ethyl-2H-chromen | 7734-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (+/-)-2-Ethyl-2H-chromen
• 英文别名: 2-ethyl-2H-chromene
• CAS: 7734-60-3
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: PDBWWVFLJFATMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF
  申请人：SHANGHAI DE NOVO PHARMATECH CO. LTD.

  公开号：US20170037038A1

  公开（公告）日：2017-02-09

  This invention relates to a kind of C-aryl glycoside derivatives, its pharmaceutical compositions, preparation methods, and uses thereof. The preparation method comprises: method 1: in a solvent, deprotecting the acetyl protecting groups of compound 1-f in the presence of a base; method 2: 1) compound 2-g reacts with via Mitsunobu reaction; 2) deprotecting the acetyl protecting groups of compound 2-f obtained from step 1; method 3: 1) compound 2-g reacts with via nucleophilic substitution reaction; 2) deprotecting the acetyl protecting groups of compound 3-f obtained from step 1. The pharmaceutical composition comprises a kind of C-aryl glycoside derivatives; it's pharmaceutically acceptable salts and/or prodrugs thereof and excipient thereof. This invention further relates to a kind of C-aryl glycoside derivatives, it's pharmaceutically acceptable salts or pharmaceutical compositions thereof for the use in preparation of a SGLT inhibitor. The C-aryl glycoside derivatives of this invention provides a new direction for the study of SGLT inhibitors.

  这项发明涉及一种C-芳基糖苷衍生物，其药物组合物、制备方法及其用途。制备方法包括：方法1：在溶剂中，在碱的存在下去保护化合物1-f的乙酰保护基；方法2：1）化合物2-g通过Mitsunobu反应发生反应；2）去除从步骤1得到的化合物2-f的乙酰保护基；方法3：1）化合物2-g通过亲核取代反应发生反应；2）去除从步骤1得到的化合物3-f的乙酰保护基。药物组合物包括一种C-芳基糖苷衍生物；其药学上可接受的盐和/或前药以及赋形剂。这项发明还涉及一种C-芳基糖苷衍生物，其药学上可接受的盐或其药物组合物，用于制备SGLT抑制剂。这项发明的C-芳基糖苷衍生物为SGLT抑制剂的研究提供了新的方向。
• Novel compound for color-producing composition, and recording material
  申请人：——

  公开号：US20010044553A1

  公开（公告）日：2001-11-22

  A urea-urethane compound having one or more urea groups and one or more urethane groups in the molecular structure, the number of said urea groups (A) and the number of said urethane groups (B) satisfying the following numerical formula: 10≧( A+B )≧3 wherein each of A and B is an integer of 1 or more.

  分子结构中含有一个或多个脲基和一个或多个脲酯基的脲酯化合物，其中所述脲基（A）的数量和所述脲酯基（B）的数量满足以下数值公式：10≤(A+B)≤3 ，其中A和B均为1或更多的整数。
• NOVEL COMPOUND FOR COLOR-PRODUCING COMPOSITION, AND RECORDING MATERIAL
  申请人：KABASHIMA Kazuo

  公开号：US20100105941A1

  公开（公告）日：2010-04-29

  A urea-urethane compound having one or more urea groups and one or more urethane groups in the molecular structure, the number of said urea groups (A) and the number of said urethane groups (B) satisfying the following numerical formula: 10≧( A+B )≧3 wherein each of A and B is an integer of 1 or more.

  一种尿素-脲化合物，其分子结构中具有一种或多种尿素基团和一种或多种脲基团，其中所述尿素基团（A）的数量和所述脲基团（B）的数量满足以下数值公式：10≥（A+B）≥3，其中A和B均为1或更多的整数。
• THERMAL RECORDING MATERIAL AND NOVEL CRYSTAL OF BISPHENOL S DERIVATIVE
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP0913267A1

  公开（公告）日：1999-05-06

  A heat-sensitive recording material in which a heat-sensitive color-developing layer comprising, as the main components, a usually colorless or light-colored color former and a developer capable of developing the color former upon heating on a support, characterized by comprising, as the developer, crystals of 3,3'-diallyl-4,4'-dihydroxy-diphenyl sulfone which have DSC (Te) of at least 149°C and which are of a crystal form characterized by an X-ray diffraction pattern having peaks at least at diffraction angles (2θ) [°] of 7.2 and 22.0, obtained by an X-ray powder diffractometry using Cu-Kα rays. This heat-sensitive recording material is high in sensitivity, little in Discoloration of the ground in heat and moisture and excellent in image durability.

  一种热敏记录材料，其热敏显色层的主要成分包括通常为无色或浅色的显色剂和在支持物上加热后能使显色剂显色的显影剂，其特征在于包括、作为显影剂，3,3'-二烯丙基-4,4'-二羟基二苯砜的晶体，其 DSC（Te）至少为 149°C，其晶体形态的 X 射线衍射图的特征是至少在衍射角（2θ）[°]为 7.2 和 22.0 的 X 射线粉末衍射图。这种热敏记录材料灵敏度高，在高温和潮湿条件下地面变色小，图像耐久性好。
• NOVEL COLOR-DEVELOPING COMPOUND AND RECORDING MATERIAL
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1116713A1

  公开（公告）日：2001-07-18

  A urea-urethane compound having one or more urea groups and one or more urethane groups in the molecular structure, the number of said urea groups (A) and the number of said urethane groups (B) satisfying the following numerical formula:         10 ≧ (A + B) ≧ 3 wherein each of A and B is an integer of 1 or more.

  一种脲-氨基甲酸酯化合物，其分子结构中含有一个或多个脲基团和一个或多个氨基甲酸酯基团，所述脲基团（A）的数目和所述氨基甲酸酯基团（B）的数目满足以下数值公式： 10 ≧ (A + B) ≧ 3 其中 A 和 B 均为 1 或 1 以上的整数。