(4Z)-3-isopropyl-2,6-dimethyl-6-(triethylsiloxy)-2,4-heptadiene | 201276-08-6

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (4Z)-3-isopropyl-2,6-dimethyl-6-(triethylsiloxy)-2,4-heptadiene
• 英文别名: [(3Z)-2,6-dimethyl-5-propan-2-ylhepta-3,5-dien-2-yl]oxy-triethylsilane
• CAS: 201276-08-6
• 化学式: C₁₈H₃₆OSi
• 分子量: 296.569
• InChiKey: BLZVDDXKLKWEGQ-YPKPFQOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.34
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4Z)-3-isopropyl-2,6-dimethyl-6-(triethylsiloxy)-2,4-heptadiene 在 desilylation reagent 、 氧气 、 tetraphenylporphyrin 、 三苯基膦 作用下， 生成 (3Z)-5-isopropylidene-2,6-dimethyl-3-heptene-2,6-diol 、 3-isopropyl-2,6-dimethyl-3,4-heptadiene-2,6-diol 、 (4Z)-3-isopropyl-2,6-dimethyl-1,4-heptadiene-3,6-diol 、 3-(1-hydroxy-1-methylethyl)-2,6-dimethyl-3,4-heptadiene-2,6-diol
  参考文献：
  名称：

  Further demonstration of the higher reactivity of the vinyl hydrogen rather than the allyl hydrogen towards singlet oxygen

  摘要：

  在一种新的线性扭曲的1,3-二烯中，观察到乙烯氢相对于仲烯氢对单态氧的异常高反应性。

  DOI：

  10.1039/a705924h
• 作为产物：
  描述：

  2,4-二甲基-3-戊酮 在 Lindlar's catalyst 4-二甲氨基吡啶 、 四(三苯基膦)钯 、 氢气 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (4Z)-3-isopropyl-2,6-dimethyl-6-(triethylsiloxy)-2,4-heptadiene
  参考文献：
  名称：

  Further demonstration of the higher reactivity of the vinyl hydrogen rather than the allyl hydrogen towards singlet oxygen

  摘要：

  在一种新的线性扭曲的1,3-二烯中，观察到乙烯氢相对于仲烯氢对单态氧的异常高反应性。

  DOI：

  10.1039/a705924h

文献信息

• Photosensitized Oxygenation of Twisted 1,3-Dienes:  Abnormally Higher Reactivity of Vinyl Hydrogen Rather than Allyl Hydrogen toward Singlet Oxygen
  作者：Hajime Mori、Keiichi Ikoma、Sachihiko Isoe、Kazuo Kitaura、Shigeo Katsumura

  DOI：10.1021/jo980955o

  日期：1998.11.1

  As one of the novel examples to investigate the characteristic reactivity of significantly twisted 1,3-dienes, the photosensitized oxygenation of two types of significantly twisted 1,3-dienes, cis-beta-ionol derivative 2 and acyclic derivative Il, is investigated. Photosensitized oxygenation of 2a-f and 11a-e revealed that the vinyl hydrogen Ha was more reactive than the allyl hydrogen Hb. Thus, phenyl derivative 2e and tert-butyl-substituted compound lid selectively produced allenes 3e and 13d in 67% and 75% yield resulting from the ene reaction of the vinyl hydrogen Ha rather than allyl alcohols 4e and 14d resulting from the allyl hydrogen abstraction in 24% and 8% yield, respectively. Furthermore, in the case of methyl-substituted compound 11b, the extent of the inherent reactivity of the vinyl hydrogen Ha was similar to that of the allyl hydrogen He. On the basis of X-ray analysis and NIM and MO calculations, the discovered abnormally higher reactivity of the vinyl hydrogen would be rationalized by considering mainly the large sigma*-pi orbital interaction between the vinyl C-H bond and another double bond in significantly twisted 1,3-dienes resulting from calculations of HOMO electron densities.