(S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride | 83552-41-4

• 英文名称: (S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride
• 英文别名: 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid hydrochloride, (S)-；(8S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;hydrochloride
• CAS: 83552-41-4
• 化学式: C₇H₁₁NO₂S₂*ClH
• 分子量: 241.763
• InChiKey: WZMQRPYFALOOHU-JEDNCBNOSA-N

物化性质

• 熔点：
  229-231 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.03
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  99.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride 在 氯化亚砜 作用下， 以 甲醇 为溶剂， 生成 1,4-dithia-7-azaspiro<4.4>nonane-8-(S)-carboxylic acid methyl ester hydrochloride
  参考文献：
  名称：

  Carboxyalkyl amino acid derivatives of various substituted prolines

  摘要：

  公开了化学式为##STR1##的羧基烷基二肽，其中R.sub.4是3-、4-、5-或4,4-取代的脯氨酸。这些化合物由于其抑制血管紧张素转化酶活性而可用作降压药物。

  公开号：

  US04462943A1
• 作为产物：
  描述：

  N-<(phenylmethoxy)carbonyl>-1,4-dithia-7-azaspiro<4.4>nonane-8(S)-carboxylic acid 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 (S)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid, hydrochloride
  参考文献：
  名称：

  Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines

  摘要：

  Analogues of captopril, enalaprilat, and the phosphinic acid [hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline incorporating 4-substituted proline derivatives have been synthesized and evaluated as inhibitors of angiotensin-converting enzyme (ACE) in vitro and in vivo. The 4-substituted prolines, incorporating alkyl, aryl, alkoxy, aryloxy, alkylthio, and arylthio substituents were prepared from derivatives of 4-hydroxy- and 4-ketoproline. In general, analogues of all three classes of inhibitors with hydrophobic substituents on proline were more potent in vitro than the corresponding unsubstituted proline compounds. 4-Substituted analogues of captopril showed greater potency and duration of action than the parent compound as inhibitors of the angiotensin I induced pressor response in normotensive rats. The S-benzoyl derivative of cis-4-(phenylthio)captopril, zofenopril, was found to be one of the most potent compounds of this class and is now being evaluated clinically as an antihypertensive agent. In the phosphinic acid series, the 4-ethylenethioketal and trans-4-cyclohexyl derivatives were found to be the most potent compounds in vitro and in vivo. A prodrug of the latter compound, fosinopril, is also being evaluated in clinical trials.

  DOI：

  10.1021/jm00401a014

文献信息

• Substituted peptide compounds
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04470973A1

  公开（公告）日：1984-09-11

  Substituted peptide compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

  揭示了公式##STR1##的替代肽化合物。由于其抑制血管紧张素转换酶的活性，这些化合物可用作降压剂，并根据X的定义，也可能由于其脑啡肽酶抑制活性而用作镇痛剂。
• KRAPCHO, JOHN;TURK, CHESTER;CUSHMAN, DAVID W.;POWELL, JAMES R.;DEFORREST,+, J. MED. CHEM., 31,(1988) N 6, C. 1148-1160
  作者：KRAPCHO, JOHN、TURK, CHESTER、CUSHMAN, DAVID W.、POWELL, JAMES R.、DEFORREST,+

  DOI：——

  日期：——