[(3-Bromo-7-cyanonaphthalen-2-yl)-difluoromethyl]-(2,2-dimethylpropanoyloxymethoxy)phosphinic acid | 1471288-44-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [(3-Bromo-7-cyanonaphthalen-2-yl)-difluoromethyl]-(2,2-dimethylpropanoyloxymethoxy)phosphinic acid
• CAS: 1471288-44-4
• 化学式: C₁₈H₁₇BrF₂NO₅P
• 分子量: 476.211
• InChiKey: YSOVETIMYKSSOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• FUSED AROMATIC PHOSPHONATE DERIVATIVES AS PRECURSORS TO PTP-1B INHIBITORS
  申请人：KANEQ PHARMA INC.

  公开号：US20150057220A1

  公开（公告）日：2015-02-26

  Fused aromatic phosphonates of structural formula I are precursors to inhibitors of protein tyrosine phosphatase-1B (PTP-1B). The compounds of the present invention are therefore useful for the treatment in a mammal of a disorder, condition, or disease responsive to inhibition of protein tyrosine phosphatase-1B, including Type 2 diabetes, insulin resistance, a lipid disorder, obesity, Metabolic Syndrome, and cancer.