N-[4-(Butylsulfamoyl)-2-nitrophenyl]-1-hydroxynaphthalene-2-carboximidic acid | 55329-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[4-(Butylsulfamoyl)-2-nitrophenyl]-1-hydroxynaphthalene-2-carboximidic acid
• 英文别名: N-[4-(butylsulfamoyl)-2-nitrophenyl]-1-hydroxynaphthalene-2-carboxamide
• CAS: 55329-17-4
• 化学式: C21H21N3O6S
• 分子量: 443.5
• InChiKey: HQJDSFSMUIFQCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• UBIQUITIN-SPECIFIC PEPTIDASE 24 INHIBITOR, MEDICINAL COMPOSITION INCLUDING THE SAME AND METHOD OF DELAYING OR REVERSING MULTIDRUG RESISTANCE IN CANCERS USING THE SAME
  申请人：NATIONAL CHENG KUNG UNIVERSITY

  公开号：US20220024887A1

  公开（公告）日：2022-01-27

  The present invention relates to a ubiquitin-specific peptidase 24 inhibitor, a medicinal composition including the same and a method of delaying or reversing multidrug resistance in cancers using the same. The USP24 inhibitor, which includes a shUSP24 RNA and/or a carbonyl substituted phenyl compound, can serve as a chemosensitizing agent for inhibiting the drug pump out, cancer sternness and genomic instability of cancer cells, thereby being applied to a medicinal composition and a method for delaying or reversing multidrug resistance in cancers.

  本发明涉及一种泛素特异性肽酶24抑制剂、包括该抑制剂的药物组合物以及使用该抑制剂延迟或逆转多药耐药性的方法。该USP24抑制剂包括shUSP24 RNA和/或羰基取代苯基化合物，可作为化疗增敏剂，抑制癌细胞的药物泵出、癌症干细胞和基因组不稳定性，因此可应用于延迟或逆转多药耐药性的药物组合物和方法。
• Cavity Induced Allosteric Modification Of Intermolecular Interactions And Methods Of Identifying Compounds That Effect The Same
  申请人：MURALI Ramachandran

  公开号：US20100151507A1

  公开（公告）日：2010-06-17

  Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
• UBIQUITIN-SPECIFIC PEPTIDASE 24 INHIBITOR, MEDICINAL COMPOSITION AND METHOD OF DELAYING OR REVERSING MULTIDRUG RESISTANCE IN CANCERS USING THE SAME
  申请人：NATIONAL CHENG KUNG UNIVERSITY

  公开号：US20220025375A1

  公开（公告）日：2022-01-27

  The present invention relates to a ubiquitin-specific peptidase 24 inhibitor, a medicinal composition and a method of delaying or reversing multidrug resistance in cancers using the same. The USP24 inhibitor, which includes a shUSP24 RNA and/or a carbonyl substituted phenyl compound, can serve as a chemosensitizing agent for inhibiting the drug pump out, cancer stemness and genomic instability of cancer cells, thereby being applied to a medicinal composition and a method for delaying or reversing multidrug resistance in cancers.
• US7653495B1
  申请人：——

  公开号：US7653495B1

  公开（公告）日：2010-01-26
• US8019557B2
  申请人：——

  公开号：US8019557B2

  公开（公告）日：2011-09-13