4-(4-phenyl-piperazin-1-yl)-butan-1-ol | 92493-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-phenyl-piperazin-1-yl)-butan-1-ol
• 英文别名: 4-(4-phenyl-piperazino)-butan-1-ol；1-<4-Hydroxy-butyl>-4-phenyl-piperazin；4-(4-Phenylpiperazin-1-yl)butan-1-ol
• CAS: 92493-12-4
• 化学式: C₁₄H₂₂N₂O
• mdl: MFCD12423036
• 分子量: 234.341
• InChiKey: CYUCDUOAHHUCLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-phenyl-piperazin-1-yl)-butan-1-ol 以 乙醚 、 氯仿 为溶剂， 反应 8.0h， 生成 1-[4-(2-Ethylsulfanyl-2,2-diphenyl-acetoxy)-butyl]-1-methyl-4-phenyl-piperazin-1-ium; iodide
  参考文献：
  名称：

  Structure–activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters unexpected agonistic activity in a series of muscarinic antagonists

  摘要：

  As a continuation of previous research on anticholinergic drugs derived from 2,2-diphenyl-2-ethylthioacetic acid, several 5,5-diphenyl-5-ethylthio-2-pentynamines (2-11) were synthetised and their antimuscarinic activity on M1-4 receptor subtypes was evaluated by functional tests and binding experiments. One of the compounds obtained showed unexpected agonistic activity in functional experiments on M-2 receptors. Since the compound carried a phenylpiperazine moiety, other similar compounds (12-17) were prepared and found to be endowed with similar behaviour. These ligands, although possessing the bulky structure characterising muscarinic antagonists, display agonistic activity at M-2 subtypes while, as expected, behaving as antagonists on M-3 and Mg subtypes. On M-1 subtypes, they show agonistic activity which, however, is not blocked by atropine. The peculiar pharmacological profile of these compounds is of interest for studying muscarinic receptor subtypes. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00332-1
• 作为产物：
  描述：

  N-苯基哌嗪 、 4-氯丁醇 生成 4-(4-phenyl-piperazin-1-yl)-butan-1-ol
  参考文献：
  名称：

  alpha, omega-Amino Alcohols. I. N-Phenyl-N′-(ω-hydroxyalkyl)-piperazines from α,ω-Chlorohydrins. Derivatives of Piperazine. XVII

  摘要：

  DOI：

  10.1021/ja01267a062

文献信息

• 1,4-dihydropyridine derivatives
  申请人：FUJIREBIO INC.

  公开号：EP0400660A1

  公开（公告）日：1990-12-05

  1,4-Dihydropyridine derivatives of formula (I): wherein Ar1 and Ar2 each represent an unsubstituted or substituted aromatic hydrocarbon or aromatic heterocyclic group; and R1 represents -C02R2, -SO2R3, -COR4, -CON(R5)2, -CN or -NO2 in which R2 is hydrogen, a straight chain, branched chain or cyclic saturated hydrocarbon group, which may have a substituent or a straight chain, branched chain or cyclic unsaturated hydrocarbon group having 2 to 10 carbon atoms, which may have a substituent, R3 is an alkyl group having 1 to 4 carbon atoms, R4 is an alkyl group having 1 to 4 carbon atoms or a phenyl group; and R5 is an alkyl group having 1 to 4 carbon atoms.

  式(I)的 1,4-二氢吡啶衍生物： 其中 Ar1 和 Ar2 各自代表未取代或取代的芳香烃或芳香杂环基团； 和 R1 代表-C02R2、-SO2R3、-COR4、-CON(R5)2、-CN 或 -NO2，其中 R2 是氢、直链、支链或环状饱和烃基（可有取代基）或具有 2 至 10 个碳原子的直链、支链或环状不饱和烃基（可有取代基），R3 是具有 1 至 4 个碳原子的烷基，R4 是具有 1 至 4 个碳原子的烷基或苯基； R5 是具有 1 至 4 个碳原子的烷基。
• 1,4-Dihydropyridine derivatives and methods of producing the same
  申请人：FUJIREBIO INC.

  公开号：EP0488345A1

  公开（公告）日：1992-06-03

  1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.

  本发明公开了具有基于钙拮抗和 PAF 拮抗的血管扩张活性的下式 1,4-二氢吡啶衍生物和光学活性 1,4-二氢吡啶衍生物，以及生产这些衍生物的方法： 其中(*)表示光学活性 1,4-二氢吡啶衍生物的手性中心。
• Arylazostilbene und -tolane durch Heck-Reaktion
  作者：Cheung-Bok Jeoung、Oliver Haak、Walter Grahn、Peter Boldt

  DOI：10.1002/prac.19933350605

  日期：——

  The palladium-catalysed coupling of p-bromo azo dyes 4 with styrenes 6 and arylacetylenes 9 provides arylazostilbenes 7 and -tolanes 10, respectively, in fair-to-good yields. Likewise, coupling of azoxy compound 5 with styrenes 6 forms the arylazoxystilbenes 8 in high yields. The influence of substituentes on light absorption of the new dyes as well as on the the C-13-NMR shifts of the azotolanes 10 are discussed.
• US5276150A
  申请人：——

  公开号：US5276150A

  公开（公告）日：1994-01-04
• US5367081A
  申请人：——

  公开号：US5367081A

  公开（公告）日：1994-11-22