6-methyl-3-[(4-phenyl-1-piperazinyl)carbonyl]-2-pyridinol | 648421-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-methyl-3-[(4-phenyl-1-piperazinyl)carbonyl]-2-pyridinol
• 英文别名: 6-methyl-3-(4-phenylpiperazine-1-carbonyl)-1H-pyridin-2-one
• CAS: 648421-93-6
• 化学式: C₁₇H₁₉N₃O₂
• 分子量: 297.357
• InChiKey: WKBXHHBHHNNLJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-羟基-6-甲基烟酸 、 N-苯基哌嗪 在 三氟乙酸 作用下， 以 水 、 乙腈 为溶剂， 生成 6-methyl-3-[(4-phenyl-1-piperazinyl)carbonyl]-2-pyridinol
  参考文献：
  名称：

  Substituted pyridines having antiangiogenic activity

  摘要：

  具有以下化学式的化合物是抑制血管生成的抑制剂。还公开了含有这些化合物的组合物、制备这些化合物的方法以及使用这些化合物进行治疗的方法。

  公开号：

  US20040014744A1

文献信息

• AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY
  申请人：Abbott Laboratories

  公开号：EP1494672A1

  公开（公告）日：2005-01-12
• [EN] AMINOCARBONYL SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES AND TRIAZINES HAVING ANTIANGIOGENIC ACTIVITY<br/>[FR] PYRIDINES, PYRIDAZINES, PYRIMIDINES, PYRAZINES ET TRIAZINES A SUBSTITUTION AMINOCARBONYLE ET A ACTIVITE ANTIANGIOGENE
  申请人：ABBOTT LAB

  公开号：WO2003086398A1

  公开（公告）日：2003-10-23

  Compounds having the formula (I) are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds. A is selected from the group consisting of pyridine, pyridine N-oxide, pyridazine, pyrimidine. pyrazine, and triazine; R1 and R2, together with the nitrogen atom to which they are attached, form a five - to eight - membered ring containing an additional zero to two heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur; wherein the ring can be optionally substituted with one, two, or three substituents independently selected from the group consisting of alkoxyalkyl, alkoxycarbonyl, alkyl, unsubstituted alkylcarbonyl, amino, aminocarbonyl, aryl, arylalkoxycarbonyl, wylalkyl, carboxy, formyl, haloalkyl, heterocycle, (heterocycle)alkyl, hydroxy, hydroxyalkoxyalkyl, hydroxyalkyl, and spiroheterocycle; R3 at each occurance is independently selected from the group consisting 'of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkyl, unsubstituted alkylcarbonyl, alkylsulfanyl, amino, aminocarbonyl, aryl, arylalkyl, aryloxy, cyano, cyanoalkyl, cyanoalkyl, (cycloalkyl)alkyl, halo, haloalkyl, heterocycle, hydroxy, hydroxyalkyl, and nitro; X is selected from the group consisting of O, S, and CH2; and m is 0-4.
• Substituted pyridines having antiangiogenic activity
  申请人：——

  公开号：US20040014744A1

  公开（公告）日：2004-01-22

  Compounds having the formula 1 are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

  具有以下化学式的化合物是抑制血管生成的抑制剂。还公开了含有这些化合物的组合物、制备这些化合物的方法以及使用这些化合物进行治疗的方法。